Related Experiment Video
Updated: Jun 4, 2026

Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry
Published on: March 7, 2019
Marked relationship between matrix metalloproteinase 7 and brain atrophy in HIV infection
Ann B Ragin1, Ying Wu, Renee Ochs
1Department of Radiology, Northwestern University, 737 N. Michigan Avenue, Suite 1600, Chicago, IL 60611-2927, USA. ann-ragin@northwestern.edu
Abstract:
Circulating levels of matrix metalloproteinases (MMP-1 and 7) have been found to correlate with the severity of brain injury in HIV-infected subjects. This study used high-resolution neuroanatomic imaging and automated segmentation algorithms to clarify this relationship. Both metalloproteinases were significantly correlated with increased cerebrospinal fluid volume fraction. Comprehensive brain volumetric analysis revealed a more marked relationship with atrophy for MMP-7, which was significantly correlated with neural injury in multiple brain regions and nearly all ventricular measurements. MMP-7 was also correlated with measures of virologic and cognitive status.
Related Concept Videos
Role of Matrix Metalloproteases in Degradation of ECM
A...
Cryptococcal Meningitis
