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Updated: Jun 4, 2026

Immunopeptidomics: Isolation of Mouse and Human MHC Class I- and II-Associated Peptides for Mass Spectrometry Analysis
Published on: October 15, 2021
Split of HLA-DRw2 into subtypic specificities closely correlated to two HLA-D products
P Richiardi1, M Belvedere, I Borelli
1Centro CNR Immunogenetica ed Istocompatibilità, Institute of Medical Genetics, University of Turin, Via Santena 19, 10126, Turin, Italy.
Abstract:
Two B-lymphocyte-specific human alloantisera were studied, PA59 and 51.23. They identify two new HLA-DR alleles, which are both subtypic to HLA-DRw2. Moreover, they are closely correlated with two HLA-D products, Dw2 and tb24 (tb24 is a new specificity described by our group). Thus, DRw2 can be "split" into two subtypic specificities that have been named TO60 and TO61, which appear more strongly correlated with HLA-D antigens. Absorption studies demonstrated cytotoxicity-negative, absorption-positive (CYNAP) reactions, and cross-reactive groups of antibodies.
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