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[Diastolic function in Chagas disease].

R A Migliore1, F T Guerrero, A Armenti

  • 1Servicio de Cardiología, Hospital Mariano R. Castex, San Martín, Prov. Buenos Aires, Argentina.

Medicina
|January 1, 1990
PubMed
Summary

Diastolic dysfunction in Chagas disease (ECh) can be detected early. Alterations in diastolic function precede systolic changes, allowing for noninvasive diagnosis of myocardial damage.

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Area of Science:

  • Cardiology
  • Infectious Diseases
  • Medical Diagnostics

Background:

  • Chagas disease (ECh) is a parasitic infection with significant cardiac implications.
  • Cardiac involvement in ECh can lead to heart failure and other complications.
  • Early detection of cardiac damage is crucial for patient management.

Purpose of the Study:

  • To analyze diastolic function in patients with Chagas disease (ECh).
  • To investigate whether diastolic function alterations precede systolic changes in ECh.
  • To evaluate the utility of noninvasive techniques for early detection of myocardial damage in ECh.

Main Methods:

  • Studied 42 patients (31 male, 11 female) with varying ECh serology status.
  • Utilized 2D echocardiography (Echo) and simultaneous electrocardiogram (EKG), phonocardiogram, and apexcardiogram.

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  • Measured various echocardiographic and apexcardiographic parameters, including diastolic function indexes (FD).
  • Classified patients into four groups based on serology, EKG, and echocardiographic findings.

    • Main Results:

    • Patients with positive ECh serology showed significant modifications in diastolic function indexes.
    • Group B (positive serology, normal EKG/Echo) and Group D (positive serology, abnormal EKG, cardiomegaly) exhibited notable diastolic dysfunction.
    • A progressive worsening of diastolic function was observed from Group B to Group D.
    • Diastolic alterations were found to precede systolic changes in ECh patients.

    Conclusions:

    • Diastolic dysfunction is a significant finding in Chagas disease (ECh).
    • Alterations in diastolic function occur early in the disease process, preceding systolic impairment.
    • Noninvasive echocardiographic techniques can facilitate early detection of myocardial damage in ECh.