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Related Concept Videos

Chronic Obstructive Pulmonary Disease I: Introduction01:23

Chronic Obstructive Pulmonary Disease I: Introduction

Chronic obstructive pulmonary disease is a common, preventable, and treatable respiratory disorder characterized by persistent symptoms and progressive airflow limitation. This limitation results from a combination of small-airway disease (obstructive bronchiolitis) and parenchymal destruction (emphysema), both driven by chronic inflammation from exposure to harmful particles or gases.The disease includes two main pathological entities: emphysema, marked by destruction of alveolar walls and...
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Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...
Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
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Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

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Related Experiment Video

Updated: Jun 4, 2026

Identification and Characterization of Immunogenic RNA Species in HDM Allergens that Modulate Eosinophilic Lung Inflammation
08:44

Identification and Characterization of Immunogenic RNA Species in HDM Allergens that Modulate Eosinophilic Lung Inflammation

Published on: May 30, 2020

Genetic predisposition to diffuse panbronchiolitis.

Naoto Keicho1, Minako Hijikata

  • 1Department of Respiratory Diseases, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan. nkeicho-tky@umin.ac.jp

Respirology (Carlton, Vic.)
|February 10, 2011
PubMed
Summary
This summary is machine-generated.

Diffuse panbronchiolitis involves airway inflammation and infection, historically with poor prognosis. Genetic studies in East Asians suggest susceptibility genes near HLA-A and HLA-B loci, prompting research into novel mucin-like genes.

Related Experiment Videos

Last Updated: Jun 4, 2026

Identification and Characterization of Immunogenic RNA Species in HDM Allergens that Modulate Eosinophilic Lung Inflammation
08:44

Identification and Characterization of Immunogenic RNA Species in HDM Allergens that Modulate Eosinophilic Lung Inflammation

Published on: May 30, 2020

Area of Science:

  • Immunogenetics
  • Pulmonology
  • Molecular Biology

Background:

  • Diffuse panbronchiolitis is a chronic inflammatory airway disease often linked to sinobronchial infections.
  • Pathophysiology includes immune cell accumulation, mucus hypersecretion, and neutrophilic infiltration in airways.
  • Historically, prognosis was poor before the advent of long-term macrolide therapy.

Purpose of the Study:

  • To investigate the genetic underpinnings of diffuse panbronchiolitis, particularly in East Asian populations.
  • To identify potential susceptibility genes located in the human leukocyte antigen (HLA) region.
  • To explore the role of novel mucin-like genes in the disease's pathogenesis.

Main Methods:

  • Analysis of immunogenetic associations, including human leukocyte antigen (HLA) typing.
  • Case study reviews focusing on East Asian populations (Japanese, Koreans, Chinese).
  • Cloning and characterization of novel mucin-like genes within a candidate chromosomal region.

Main Results:

  • Strong association found between HLA-B54 and diffuse panbronchiolitis in Japanese individuals.
  • Association reported between HLA-A11 and the disease in Korean populations.
  • Novel mucin-like genes were successfully cloned from the HLA-A to HLA-B locus region.

Conclusions:

  • Genetic predisposition, potentially linked to specific HLA alleles, plays a role in diffuse panbronchiolitis susceptibility in Asians.
  • The identified candidate region on chromosome 6 is crucial for further investigation.
  • Newly identified mucin-like genes warrant further study for their contribution to diffuse panbronchiolitis pathogenesis.