Related Experiment Video
Updated: Jun 4, 2026
07:30
Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
Published on: April 23, 2021
Cerebrovascular symptomatic involvement in sarcoidosis
A Degardin1, P Devos, P Vermersch
1Department of Neurology, CHRU Lille, France. a-degardin@chru-lille.fr
Acta Neurologica Belgica
|February 11, 2011
Summary
Cerebral pseudotumoral sarcoidosis is rare, presenting as brain hematomas and sinus occlusion. This case highlights the importance of considering sarcoidosis in neurological presentations, even with rare cerebrovascular involvement.
Area of Science:
- Neurology
- Immunology
- Pathology
Background:
- Sarcoidosis is a multisystem inflammatory disease.
- Cerebrovascular involvement in sarcoidosis is infrequently reported clinically.
- Granulomatous lesions in cerebral arteries and veins are common pathologically.
Observation:
- A 47-year-old man with a history of pulmonary sarcoidosis and abducens palsy presented with acute hemiplegia.
- Brain imaging revealed a hematoma and superior sagittal sinus occlusion.
- The patient developed status epilepticus and new hematomas, with angiography showing vasculitis.
Findings:
- Histologically confirmed cerebral pseudotumoral sarcoidosis.
- Demonstration of rare cerebrovascular complications including sinus thrombosis and vasculitis.
- Successful management with corticosteroids and anticoagulation.
Implications:
- This case underscores the potential for severe, rare neurological manifestations of sarcoidosis.
- Highlights the diagnostic challenge of pseudotumoral sarcoidosis.
- Emphasizes the need for early recognition and multidisciplinary management of neurosarcoidosis.
Related Concept Videos
01:22Cerebral Edema ll: Pathophysiology
Vasogenic edema is a major form of cerebral edema characterized by abnormal accumulation of fluid in the brain’s extracellular space due to disruption of the blood–brain barrier (BBB). The BBB is a specialized structure composed of endothelial cells connected by tight junctions, supported by astrocytic endfeet and a basement membrane. Under normal conditions, it tightly regulates the movement of ions, proteins, and solutes between the bloodstream and brain parenchyma. When this barrier loses...
01:29Hemorrhagic Stroke ll: Pathophysiology
A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...
01:21Aneurysm II: Clinical Manifestations and Diagnostic Studies
Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
01:17Hemorrhagic Stroke l: Introduction
A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...
01:29Increased Intracranial Pressure ll: Pathophysiology
Increased intracranial pressure (ICP) refers to a potentially life-threatening rise in pressure inside the skull. This usually happens when there is a major change in the volume of brain tissue, blood, or cerebrospinal fluid (CSF) — the three components inside the skull. According to the Monro-Kellie doctrine, if the volume of one component increases, the volumes of the other components must decrease to maintain normal pressure. If this does not happen, ICP rises.The process often begins with...
01:21Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation
Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...