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Updated: Jun 4, 2026

Establishment of an Experimental Mouse Model of Endometrioma to Study its Related Infertility
Published on: April 5, 2024
Plasminogen activator inhibitor-1 4G/5G polymorphism in infertile women with and without endometriosis
Rubens P Gonçalves-Filho1, Ariel Brandes, Denise M Christofolini
1Division of Gynecological Pathology and Human Reproduction, Department of Gynecology and Obstetrics, Faculty of Medicine of ABC, Santo André, Sao Paulo, Brazil.
Objective:
To evaluate PAI-1 genotypes in a group of infertile women with or without endometriosis and control subjects.
Design:
Case-control study.
Setting:
Human Reproduction Center of Medicina do ABC Faculty.
Population:
One hundred and forty infertile women with endometriosis, 64 women with idiopathic infertility and 148 fertile women as control subjects.
Methods:
The PAI-1 4G/5G polymorphism was identified by restriction fragment length polymorphism-polymerase chain reaction.
Main Outcome Measures:
Genotype distribution and allele frequency of the 4G/5G polymorphism of the PAI-1 gene.
Results:
The frequencies of genotypes 4G/4G, 4G/5G and 5G/5G of the PAI-1 gene in the infertile women with endometriosis were 38.6, 37.1 and 24.3%, respectively, and in the control group 24.3, 33.8 and 41.9%, respectively (p=0.003). When the infertile women with endometriosis were divided according to their endometriosis stage, genotypes 4G/4G, 4G/5G and 5G/5G were identified, respectively, in 36.7, 32.9 and 30.4% of the patients with minimal/mild endometriosis (p=0.102) and in 41.0, 42.6 and 16.4% of the patients with moderate/severe endometriosis (p=0.001); in the women with idiopathic infertility, these genotypes were found at a frequency of 29.7, 34.3 and 36%, respectively (p=0.637).
Conclusion:
The data suggest that, in Brazilian women, the PAI-1 4G/5G polymorphism may be associated with a risk of endometriosis-associated infertility.
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