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Related Concept Videos

Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
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Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in acid or...
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Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Essential Minerals for Bone Health01:31

Essential Minerals for Bone Health

The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
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Comprehensive Characterization of Tissue Mineralization in an Ex Vivo Model
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Inter-species variation in bone mineral behavior upon heating.

Sophie Beckett1, Keith D Rogers, John G Clement

  • 1Department of Engineering and Applied Science, Cranfield Forensic Institute, Cranfield University, Shrivenham, Wiltshire SN6 8LA, UK. s.beckett@cranfield.ac.uk

Journal of Forensic Sciences
|February 11, 2011
PubMed
Summary

This study reveals significant differences in bone mineral (b-HAP) characteristics across 12 species, including humans. X-ray diffraction analysis shows human bone is uniquely distinct, suggesting potential for species identification methods.

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Area of Science:

  • Forensic Science
  • Archaeology
  • Biomineralogy
  • Materials Science

Background:

  • Inter-species variation in bone mineral (b-HAP) is crucial for forensic and archaeological applications.
  • Previous research has not extensively explored these variations.

Purpose of the Study:

  • To characterize inter-species variations in bone mineral (b-HAP).
  • To investigate the behavior of bone mineral upon heating.
  • To assess the potential for developing species identification methods based on bone mineral analysis.

Main Methods:

  • Quantitative analysis of bone mineral (b-HAP) using X-ray diffraction (XRD).
  • Examination of unheated bone mineral from 12 animal species, including humans.
  • Analysis of bone samples heated to 600°C and 1400°C to observe thermal decomposition and recrystallization behavior.

Main Results:

  • Significant inter-species variations in b-HAP characteristics were observed.
  • Human bone exhibited distinct b-HAP lattice parameter values compared to all other species, both unheated and heated.
  • Unique recrystallization behavior of b-HAP was noted in human bone upon heating to 600°C.
  • Thermal decomposition products of b-HAP in human bone at 1400°C differed significantly from most other species.

Conclusions:

  • Bone mineral (b-HAP) characteristics show significant species-specific differences.
  • Human bone mineral properties are uniquely distinguishable from other species.
  • X-ray diffraction (XRD) analysis holds potential for developing reliable methods to identify bone species, particularly distinguishing human from non-human remains.