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Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

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Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...

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A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles
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Published on: December 23, 2016

Temperature-responsive ionic-crosslinked polymeric nanocapsules via 'self-templating' approach.

Yun Dong1, Bin Mu, Peng Liu

  • 1State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, People's Republic of China.

Colloids and Surfaces. B, Biointerfaces
|February 11, 2011
PubMed
Summary
This summary is machine-generated.

New temperature-responsive polymeric nanocapsules (TRICNs) were developed using a self-templating method. These nanocapsules show tunable properties, including disintegration in acidic conditions and stability in neutral/alkaline media.

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Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization
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Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization

Published on: January 24, 2025

Area of Science:

  • Polymer Science
  • Nanotechnology
  • Materials Science

Background:

  • Polymeric nanocapsules offer versatile platforms for various applications.
  • Developing stimuli-responsive materials is crucial for advanced drug delivery and sensing.
  • Existing fabrication methods can be complex and costly.

Purpose of the Study:

  • To fabricate novel temperature-responsive ionic-crosslinked polymeric nanocapsules (TRICNs).
  • To characterize the structural and thermal properties of the synthesized TRICNs.
  • To investigate the pH-dependent stability of the TRICNs.

Main Methods:

  • Fabrication of terpolymer nanoparticles via emulsifier-free emulsion polymerization.
  • Ionic crosslinking of surface carboxyl groups with calcium ions.
  • Core etching using acetone to form nanocapsules.
  • Characterization using Transmission Electron Microscopy (TEM) and Dynamic Light Scattering (DLS).

Main Results:

  • TRICNs were successfully synthesized with a particle size of approximately 200 nm and an inner diameter of about 140 nm.
  • Dynamic Light Scattering (DLS) analysis revealed a lower critical solution temperature (LCST) around 31°C.
  • The nanocapsules demonstrated disintegration in acidic media (pH < 7) and stability in neutral or alkaline media (pH >= 7).

Conclusions:

  • The developed 'self-templating' approach provides an efficient route to temperature-responsive polymeric nanocapsules.
  • TRICNs exhibit tunable thermal responsiveness and pH-dependent stability, making them promising for controlled release applications.
  • The findings open avenues for designing advanced nanocarriers with specific environmental response characteristics.