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Related Concept Videos

Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
Myocarditis I: Introduction01:21

Myocarditis I: Introduction

Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...

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Related Experiment Video

Updated: Jun 4, 2026

Tachycardia-Induced Cardiomyopathy As a Chronic Heart Failure Model in Swine
10:08

Tachycardia-Induced Cardiomyopathy As a Chronic Heart Failure Model in Swine

Published on: February 17, 2018

Septic cardiomyopathy: hemodynamic quantification, occurrence, and prognostic implications.

Karl Werdan1, Anja Oelke, Stefan Hettwer

  • 1Department of Medicine III, University of Halle (Saale), Ernst-Grube-Street 40, 06097, Halle, Germany.

Clinical Research in Cardiology : Official Journal of the German Cardiac Society
|February 11, 2011
PubMed
Summary
This summary is machine-generated.

Afterload-related cardiac performance (ACP) reliably quantifies septic cardiomyopathy in patients with septic MODS. This new parameter is crucial for assessing cardiac function and predicting outcomes in critically ill septic patients.

Related Experiment Videos

Last Updated: Jun 4, 2026

Tachycardia-Induced Cardiomyopathy As a Chronic Heart Failure Model in Swine
10:08

Tachycardia-Induced Cardiomyopathy As a Chronic Heart Failure Model in Swine

Published on: February 17, 2018

Area of Science:

  • Critical Care Medicine
  • Cardiology
  • Sepsis Research

Background:

  • Severe reduction in afterload in sepsis can mask underlying cardiac dysfunction.
  • Septic cardiomyopathy is a significant concern in patients with sepsis and multiple organ dysfunction syndrome (MODS).

Purpose of the Study:

  • To establish and validate the parameter "afterload-related cardiac performance (ACP)" to assess cardiac function in septic MODS.
  • To determine the extent, frequency, and prognostic relevance of septic cardiomyopathy using ACP.

Main Methods:

  • Conducted a 12-month study on intensive care unit patients diagnosed with septic MODS (sepsis score ≥12 and APACHE II score ≥20).
  • Utilized pulmonary artery catheterization for hemodynamic assessments.
  • Calculated ACP as the ratio of measured cardiac output to normal cardiac output, expressed as a percentage.

Main Results:

  • ACP demonstrated a stronger correlation with disease severity scores (APACHE II, sepsis score) than traditional cardiac output parameters.
  • ACP correlated with sepsis-induced myocardial damage, indicated by elevated troponin I levels.
  • ACP significantly differed between survivors (86.9%) and non-survivors (69.2%), with lower ACP values (<60%) indicating impaired cardiac function and poorer prognosis.

Conclusions:

  • Afterload-related cardiac performance (ACP) is a reliable parameter for quantifying cardiac function impairment in septic MODS.
  • Septic cardiomyopathy is frequent and holds significant prognostic value in patients with septic MODS.
  • ACP can aid in risk stratification and management of critically ill septic patients.