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Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression

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External tissue support and fluid-structure simulation in blood flows.

P Moireau¹, N Xiao, M Astorino

¹INRIA Paris-Rocquencourt, B.P.105, 78153, Le Chesnay, France. philippe.moireau@inria.fr

Biomechanics and Modeling in Mechanobiology

|February 11, 2011

Summary

This study models external tissue effects on arterial walls using viscoelastic support conditions. The approach accurately simulates thoracic aortae, validating fluid-structure interaction models with clinical data.

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Area of Science:

Biomedical Engineering
Computational Fluid Dynamics
Medical Imaging Analysis

Background:

Existing fluid-structure interaction models often neglect external tissue effects on arterial dynamics.
Accurate boundary conditions for the solid domain are crucial for realistic arterial modeling.

Purpose of the Study:

To develop a model for the external tissue environment in arterial tree studies using fluid-structure interaction.
To introduce viscoelastic support conditions to represent surrounding tissues.
To validate the model's effectiveness using patient-specific thoracic aorta data.

Main Methods:

Modeling external tissue effects with viscoelastic support conditions and two adjustable parameters.
Applying the strategy to patient-specific thoracic aorta models using clinical data.
Utilizing two distinct fluid-structure interaction methodologies: Arbitrary Lagrangian-Eulerian (ALE) and coupled momentum method.

Main Results:

Simulations demonstrated very good adequacy with dynamic image sequences in both patient cases.
The proposed viscoelastic model effectively captures the influence of external tissues.
Patient-specific modeling of thoracic aortae was successfully performed.

Conclusions:

The developed model provides adequate boundary conditions for the solid domain by incorporating viscoelastic support.
This approach enhances the accuracy of fluid-structure interaction simulations in arterial biomechanics.
The method is versatile and effective for patient-specific analysis of the thoracic aorta.