Related Experiment Video
Updated: Jun 4, 2026

Bacterial Artificial Chromosomes: A Functional Genomics Tool for the Study of Positive-strand RNA Viruses
Published on: December 29, 2015
New vaccines for Japanese encephalitis
Scott B Halstead1, Stephen J Thomas
1Research Program, Pediatric Dengue Vaccine Initiative, 5824 Edson Lane, Rockville, MD, 20852, USA, halsteads@erols.com.
Japanese encephalitis virus (JEV) causes epidemics in Asia. New safe and effective vaccines are now available, significantly reducing the burden of Japanese encephalitis (JE) disease for at-risk populations.
Area of Science:
- Virology
- Epidemiology
- Vaccinology
Background:
- Japanese encephalitis virus (JEV) is a flavivirus responsible for epidemics of encephalitis across Asia.
- Transmission occurs via the mosquito Culex tritaeniorhynchus in a zoonotic cycle, posing risks to residents and visitors in endemic areas.
- Traditional killed viral vaccines have been used for decades, but concerns regarding cost, efficacy, and safety have driven vaccine development.
Purpose of the Study:
- To review the development and availability of vaccines for Japanese encephalitis (JE).
- To highlight recent advancements in JE vaccine technology.
- To emphasize the impact of new vaccines on disease burden.
Main Methods:
- Review of historical and recent Japanese encephalitis vaccine development.
- Analysis of vaccine types including killed viral, live attenuated, and chimeric vaccines.
- Assessment of vaccine licensure and availability in key regions.
Main Results:
- Development of a single-dose live attenuated SA14-14-2 vaccine.
- Licensure of a purified inactivated JE vaccine (IC51) in the US, Europe, and Australia.
- Upcoming licensure of a live-attenuated yellow fever-JE chimeric vaccine (ChimeriVax-JE).
Conclusions:
- Safe and effective JE vaccines are now accessible to all populations at risk.
- These advancements are expected to substantially decrease the incidence and impact of Japanese encephalitis.
- The availability of diverse vaccine options addresses previous limitations in JE prevention.
More Related Videos
09:37Detection of Polyfunctional T Cells in Children Vaccinated with Japanese Encephalitis Vaccine via the Flow Cytometry Technique
Published on: September 23, 2022
06:22Standardization of Transfer across Labs between Flow Cytometers for Detection of Lymphocytes in Japanese Encephalitis Vaccinated Children
Published on: February 10, 2023
Related Concept Videos
Arboviral Encephalitis
Encephalitis l: Introduction
Encephalitis ll: Pathophysiology
Vaccines
Vaccinations
Vaccine Production