Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Hormones and Bone Tissue

Hormones and Bone Tissue

The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...

Bone Remodeling

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.

Skeleton and Calcium Homeostasis

Skeleton and Calcium Homeostasis

Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.

Chronic Kidney Disease III: Interprofessional Care

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...

Osteoclasts in Bone Remodeling

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Tamoxifen induces region-specific osteocytic recombination and transiently alters bone structure in Dmp1-Cre-ERT2 mice.

The Journal of biological chemistry·2026

Same author

Pregnancy and Lactation Associated Osteoporosis: A Systematic Review.

Calcified tissue international·2026

Same author

Fractures at virtually all sites are associated with adverse outcomes: an observational study.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research·2026

Same author

JAK1/STAT3 signalling in cortical bone development, growth and maintenance.

Biochimica et biophysica acta. Molecular cell research·2026

Same author

Clinical and prognostic significance of parathyroid hormone-related protein in breast cancer: a systematic review and meta-analyses of observational studies in women.

Endocrine-related cancer·2026

Same author

Clarifying clinically treatment-naive status for osteoporosis patients.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2026

Search research articles

Related Experiment Video

Updated: Jun 4, 2026

Use of Human Perivascular Stem Cells for Bone Regeneration

Use of Human Perivascular Stem Cells for Bone Regeneration

Published on: May 25, 2012

Skeletal recovery after weaning does not require PTHrP.

Beth J Kirby¹, Laleh Ardeshirpour, Janine P Woodrow

¹Faculty of Medicine, Memorial University of Newfoundland, St John's, Newfoundland, Canada.

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research

|February 11, 2011

Summary

Parathyroid hormone-related protein (PTHrP) is not required for bone mineral recovery after lactation in mice, despite its upregulation post-weaning. The mechanisms driving bone formation post-weaning remain unidentified.

More Related Videos

A Rat Tibial Growth Plate Injury Model to Characterize Repair Mechanisms and Evaluate Growth Plate Regeneration Strategies

A Rat Tibial Growth Plate Injury Model to Characterize Repair Mechanisms and Evaluate Growth Plate Regeneration Strategies

Published on: July 4, 2017

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy

Published on: July 14, 2023

Related Experiment Videos

Last Updated: Jun 4, 2026

Use of Human Perivascular Stem Cells for Bone Regeneration

Use of Human Perivascular Stem Cells for Bone Regeneration

Published on: May 25, 2012

A Rat Tibial Growth Plate Injury Model to Characterize Repair Mechanisms and Evaluate Growth Plate Regeneration Strategies

A Rat Tibial Growth Plate Injury Model to Characterize Repair Mechanisms and Evaluate Growth Plate Regeneration Strategies

Published on: July 4, 2017

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy

Published on: July 14, 2023

Area of Science:

Endocrinology
Bone Biology
Mouse Models

Background:

Lactation causes significant bone mineral loss in mice.
Post-weaning bone recovery mechanisms are not fully understood.
Parathyroid hormone-related protein (PTHrP) is known to play a role in bone metabolism.

Purpose of the Study:

To investigate the role of osteoblast-derived PTHrP in post-weaning bone recovery.
To determine if PTHrP is essential for restoring bone mineral content after lactation.

Main Methods:

Utilized a conditional knockout mouse model (Cre(ColI)) to delete PTHrP in preosteoblasts and osteoblasts.
Studied female mice through pregnancy, lactation, and a 3-week post-weaning recovery period.
Assessed bone mineral content (BMC) using dual-energy X-ray absorptiometry and histomorphometry.

Main Results:

Both wild-type and PTHrP knockout mice experienced similar bone mineral loss during lactation.
Both genotypes fully restored bone mineral content to baseline levels after weaning.
No significant differences in bone recovery markers (Osteocalcin, P1NP, deoxypyridinoline) were observed between genotypes.

Conclusions:

Osteoblast-derived PTHrP is not required for the recovery of bone mass after lactation in mice.
The upregulation of Pthrp mRNA post-weaning does not indicate a necessary role for PTHrP in bone recovery.
Key factors stimulating post-weaning bone formation remain to be identified.