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Updated: Jun 4, 2026
13:33
Infinium Assay for Large-scale SNP Genotyping Applications
Published on: November 19, 2013
Databases in the area of pharmacogenetics.
Sarah C Sim1, Russ B Altman, Magnus Ingelman-Sundberg
1Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden. Sarah.Sim@ki.se
Human Mutation
|February 11, 2011
Summary
Databases are crucial for pharmacogenetics, offering insights into gene variants affecting drug response and toxicity. This review highlights resources vital for personalized medicine development.
Area of Science:
- Pharmacogenetics
- Personalized Medicine
- Genomic Databases
Background:
- Variant genes encoding drug-metabolizing enzymes, transporters, and targets are critical for drug response and toxicity.
- Databases are essential for scientists, physicians, and industry to access information on these gene variants.
- Personalized medicine aims to improve drug treatment by identifying biomarkers for drug toxicity and response.
Purpose of the Study:
- To review databases providing information on gene variants impacting drug response and toxicity.
- To identify key resources for the pharmacogenomic field.
- To support the development of personalized health care.
Main Methods:
- Literature review of existing databases.
- Analysis of database content relevant to pharmacogenetics.
- Identification of databases focusing on drug-gene interactions.
Main Results:
- Several databases offer valuable information on gene variants and their impact on drug response.
- These resources facilitate the search for specific drug-gene interactions.
- The reviewed databases are beneficial for scientific research and clinical applications.
Conclusions:
- Accessible databases are fundamental for advancing pharmacogenetics and personalized medicine.
- Effective utilization of these databases can lead to improved patient outcomes.
- Continued development and curation of pharmacogenomic databases are essential.
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