Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Drug Abuse and Addiction: Pharmacological Phenomena

Drug Abuse and Addiction: Pharmacological Phenomena

Drug dependence, abuse, and addiction are complex phenomena that can precipitate various abnormal states. Physical dependence refers to a state of pharmacological adaptation to a drug. This adaptation often results in tolerance—a reduced response to the drug after repeated administrations. When the drug use is abruptly stopped, withdrawal symptoms occur due to the body's need to readjust from the pharmacologically induced imbalance. However, tolerance and withdrawal symptoms do not necessarily...

Drug Dependence

Drug Dependence

Medications are typically administered to achieve therapeutic effects. Some drugs can modify an individual's mood and perception, frequently resulting in various enjoyable experiences. However, this can result in drug dependency, a condition marked by continuous drug use despite potential negative consequences. Drug dependency primarily falls into two categories: psychological and physical dependence. Psychological dependence occurs when the pleasurable feelings induced by the drug...

Substance Use Disorders Affecting Sleep

Substance Use Disorders Affecting Sleep

Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...

Stimulants

Stimulants

Stimulants are substances that enhance neural activity and elevate dopamine levels in the brain, leading to their highly addictive nature. These drugs include cocaine, amphetamines, MDMA, caffeine, and nicotine, each with distinct mechanisms of action and varied health implications.
Cocaine can be administered via snorting, injection, or smoking. It primarily functions by blocking the reuptake of dopamine, resulting in a euphoric high characterized by an intense sensation of happiness and...

CNS Depressants: Alcohol and Nicotine

CNS Depressants: Alcohol and Nicotine

Ethanol, a clear colorless alcohol, has been consumed by humans for millennia, but its effects on the body are far from benign. At lower doses, it induces decreased inhibitions and loquaciousness, leading to its social appeal. However, it can cause severe consequences at higher doses, such as coma and respiratory depression, due to its zero-order elimination kinetics. Chronic ethanol abuse wreaks havoc on multiple organ systems, particularly the CNS and the liver. Abrupt cessation of ethanol...

Depressants

Depressants

Depressant drugs, including alcohol and sedative-hypnotics, diminish central nervous system activity by enhancing the action of gamma-aminobutyric acid (GABA), a neurotransmitter that reduces brain activity and promotes relaxation. These substances can have various therapeutic uses but also pose significant risks, especially when misused or combined.
Alcohol is a common depressant that can induce a sense of relaxation and reduced inhibition at low doses. Contrary to its occasional...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

[Sentinel program: Example of suicide prevention for an agricultural population in Switzerland].

L'Encephale·2020

Same author

Account of a Fœtus Found in the Abdomen of a Woman 83 Years of Age.

Edinburgh medical and surgical journal·2018

Same author

[Study of algorithms to identify schizophrenia in the SNIIRAM database conducted by the REDSIAM network].

Revue d'epidemiologie et de sante publique·2017

Same author

Community-acquired Clostridium difficile infections.

Medecine et maladies infectieuses·2016

Same author

Opioid maintenance therapy in Switzerland: an overview of the Swiss IMPROVE study.

Swiss medical weekly·2014

Same author

Poly a blocks in the nuclear ribonucleoprotein complexes, containing pre-mRNA.

Molecular biology reports·2013

Same journal

Revue medicale suisse·2026

Same journal

Revue medicale suisse·2026

Same journal

Revue medicale suisse·2026

Same journal

Revue medicale suisse·2026

Same journal

Revue medicale suisse·2026

Same journal

[Erythema multiforme : target deciphering].

Revue medicale suisse·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 4, 2026

Comprehensive Analysis of Transcription Dynamics from Brain Samples Following Behavioral Experience

Comprehensive Analysis of Transcription Dynamics from Brain Samples Following Behavioral Experience

Published on: August 26, 2014

[Addiction].

J Besson¹, M Monnat, J Grivel

¹Service de psychiatrie communautaire, DP-CHUV, Rue St-Martin 7, 1003 Lausanne. Jacques.Besson@chuv.ch

Revue Medicale Suisse

|February 12, 2011

Summary

This summary is machine-generated.

This review covers 2010 addiction medicine news, including cardiac risks with methadone, relational neuroscience, and trauma-addiction links. It also explores low-threshold treatment and psychodynamic approaches.

More Related Videos

A Conditioned Place Preference Protocol for Measuring Incubation of Craving in Rats

A Conditioned Place Preference Protocol for Measuring Incubation of Craving in Rats

Published on: November 6, 2018

A Procedure to Study Stress-Induced Relapse of Heroin Seeking after Punishment-Imposed Abstinence

A Procedure to Study Stress-Induced Relapse of Heroin Seeking after Punishment-Imposed Abstinence

Published on: March 23, 2022

Related Experiment Videos

Last Updated: Jun 4, 2026

Comprehensive Analysis of Transcription Dynamics from Brain Samples Following Behavioral Experience

Comprehensive Analysis of Transcription Dynamics from Brain Samples Following Behavioral Experience

Published on: August 26, 2014

A Conditioned Place Preference Protocol for Measuring Incubation of Craving in Rats

A Conditioned Place Preference Protocol for Measuring Incubation of Craving in Rats

Published on: November 6, 2018

A Procedure to Study Stress-Induced Relapse of Heroin Seeking after Punishment-Imposed Abstinence

A Procedure to Study Stress-Induced Relapse of Heroin Seeking after Punishment-Imposed Abstinence

Published on: March 23, 2022

Area of Science:

Addiction Medicine
Neuroscience
Psychotherapy

Context:

Review of 2010 developments in addiction medicine.
Focus on somatic, neuroscientific, and psychotherapeutic advancements.
Highlights include cardiac risks of methadone and relational neuroscience.

Purpose:

To summarize key findings and trends in addiction medicine for 2010.
To integrate diverse aspects of addiction treatment and research.
To bridge different theoretical and practical approaches.

Summary:

Cardiac arrhythmia risks associated with methadone racemate prescription in Switzerland were examined.
Neuroscience contributions included relational neuroscience and the link between trauma and addiction.
A psychodynamic perspective was applied to low-threshold addiction treatment.

Impact:

Provides a concise overview of critical 2010 addiction medicine research.
Informs clinicians and researchers about emerging trends and risks.
Facilitates understanding of multifaceted addiction treatment strategies.