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Related Concept Videos

Cellular Adaptation III: Hyperplasia01:26

Cellular Adaptation III: Hyperplasia

Hyperplasia is an increase in the number of cells in a tissue or organ due to enhanced cell division. It is an adaptive, controlled response to stimuli such as injury, hormones, or stress, involving mitosis to produce genetically identical cells and support tissue repair and regeneration.Tissue CapacityCertain tissues, including the epidermis, intestinal epithelium, bone marrow, and fibroblasts, have a high potential for hyperplasia. Others, such as bone, cartilage, and smooth muscle, show...
Proliferative Phase01:20

Proliferative Phase

The proliferative phase typically occurs after menstruation and lasts between 6 to 13 days in a standard 28-day cycle. This phase involves the reconstruction of the endometrium, guided by estrogen produced by the developing ovarian follicle.
Notably, the stratum basale, the basal layer of the endometrium, including the basal parts of the uterine glands, remains unaffected by menstruation. Stem cells in this layer undergo mitosis, regenerating the stratum functionalis and thickening the...
Cellular Adaptation IV: Dysplasia and Metaplasia01:24

Cellular Adaptation IV: Dysplasia and Metaplasia

DysplasiaDysplasia refers to abnormal changes in the size, shape, and organization of mature cells, characterized by pleomorphism, nuclear abnormalities, and increased mitotic activity. It commonly affects epithelial tissues, including the cervix, gastrointestinal tract, respiratory mucosa, and endometrium. Although it may occur alongside hyperplasia, dysplasia is not a true adaptive response but a preneoplastic change with potential to progress to cancer.When confined above the basement...
Disorders of the Female Reproductive System01:24

Disorders of the Female Reproductive System

The female reproductive system can be affected by several disorders, including Premenstrual Syndrome (PMS), Premenstrual Dysphoric Disorder (PMDD), endometriosis, and various forms of cancer. PMS and PMDD are cyclical conditions that cause physical and emotional distress, with symptoms that include edema, mood swings, and food cravings. PMDD is a more severe form of PMS characterized by increased symptom severity that peaks during the luteal phase and tends to improve or resolve shortly after...
Ovarian Cycle01:27

Ovarian Cycle

The menstrual cycle includes a critical component known as the ovarian cycle, which undergoes two main phases each month—the follicular phase and the luteal phase. The follicular phase is variable and averaging around 14 days. Ovulation, triggered by a surge in luteinizing hormone (LH), marks the transition between the two phases. The second phase, the luteal phase, is relatively consistent, lasting approximately 14 days, and is marked by the activity of the corpus luteum. While a cycle length...
Histology of the Uterus01:19

Histology of the Uterus

The uterine wall consists of three histological layers: the perimetrium, myometrium, and endometrium. The outermost perimetrium is a thin, serous membrane connected with the broad ligament on the sides, which helps anchor the uterus in the pelvic cavity. The thickest layer, myometrium, is mainly made up of smooth muscle tissue bundles. Its contractions are vital in facilitating the expulsion of the uterine lining, fetus, and placenta during menstruation and childbirth.
The endometrium is the...

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Updated: Jun 4, 2026

Two Methods for Establishing Primary Human Endometrial Stromal Cells from Hysterectomy Specimens
09:15

Two Methods for Establishing Primary Human Endometrial Stromal Cells from Hysterectomy Specimens

Published on: May 23, 2014

Endometrial hyperplasia.

Anne M Mills1, Teri A Longacre

  • 1Department of Pathology, Stanford University, Stanford, California 94305, USA.

Seminars in Diagnostic Pathology
|February 12, 2011
PubMed
Summary
This summary is machine-generated.

Endometrial hyperplasia encompasses a spectrum of lesions, from reversible growths to cancer precursors. Understanding diverse classification systems is crucial for accurate diagnosis and risk assessment.

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Generation of Multicellular Human Primary Endometrial Organoids
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Two Methods for Establishing Primary Human Endometrial Stromal Cells from Hysterectomy Specimens
09:15

Two Methods for Establishing Primary Human Endometrial Stromal Cells from Hysterectomy Specimens

Published on: May 23, 2014

Generation of Multicellular Human Primary Endometrial Organoids
09:20

Generation of Multicellular Human Primary Endometrial Organoids

Published on: October 4, 2019

Area of Science:

  • Gynecologic Pathology
  • Oncology
  • Histopathology

Background:

  • Endometrial hyperplasia presents a spectrum of lesions, ranging from benign proliferations to precursors of endometrial cancer.
  • These lesions exhibit a continuum of morphologic features, involving glandular architecture and cellular atypia.

Purpose of the Study:

  • To provide an overview of current endometrial hyperplasia classification systems.
  • To present histologic criteria, merits, and potential misclassification causes for each system.

Main Methods:

  • Review of established and contemporary classification systems for endometrial hyperplasia.
  • Analysis of histologic features, including glandular architecture and cytology.
  • Discussion of molecular genetic alterations relevant to risk stratification.

Main Results:

  • Endometrial hyperplasia classifications vary, often overlapping in advanced stages.
  • Histologic features (architecture and cytology) are primary diagnostic tools.
  • Different classification systems may lead to diagnostic discrepancies.

Conclusions:

  • Accurate classification of endometrial hyperplasia is essential for appropriate patient management.
  • Awareness of different systems and potential pitfalls aids in precise diagnosis.
  • Further research may refine classification based on molecular and histologic correlations.