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Related Concept Videos

Long-term Potentiation01:35

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
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Event-related Potentials During Target-response Tasks to Study Cognitive Processes of Upper Limb Use in Children with Unilateral Cerebral Palsy
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Published on: January 11, 2016

Sequence learning in cerebral palsy.

Chiara Gagliardi1, Alessandro Tavano, Anna Carla Turconi

  • 1Department of Child Neuropsychiatry and Neurorehabilitation, E. Medea Scientific Institute, Bosisio Parini, Lecco, Italy.

Pediatric Neurology
|February 12, 2011
PubMed
Summary

Children with cerebral palsy (CP) show impaired sequence learning, impacting visual memory and accuracy. Difficulty learning sequences correlates with lower overall cognitive functioning, suggesting potential implicit memory deficits in CP.

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Area of Science:

  • Neuroscience
  • Developmental Psychology
  • Pediatrics

Background:

  • Cerebral palsy (CP) affects motor skills and can impact cognitive functions.
  • Sequence learning is a key aspect of cognitive development and implicit memory.
  • Understanding cognitive profiles in children with CP is crucial for targeted interventions.

Purpose of the Study:

  • To investigate sequence-learning abilities in children with cerebral palsy (CP) compared to typically developing controls.
  • To examine the relationship between sequence learning, motor impairments, and general cognitive abilities in children with CP.
  • To explore the potential link between sequence learning deficits and underlying neurological differences in CP.

Main Methods:

  • Assessed sequence-learning skills using computerized Corsi Span and Supraspan tasks in 64 children with CP and matched controls.
  • Classified motor and handling abilities using the Gross Motor Function Classification System and Manual Ability Classification System.
  • Evaluated general cognitive, visuoperceptual, and constructive abilities in all participants.

Main Results:

  • Children with CP demonstrated significantly poorer performance in visual memory and accuracy compared to controls.
  • A higher proportion of children with CP failed the sequence learning tasks (37.5%) versus controls (5%).
  • Sequence learning ability, not motor impairment, differentiated high-functioning from low-functioning children with CP, correlating with overall cognitive profiles.

Conclusions:

  • Children with CP exhibit specific deficits in sequence learning, potentially linked to implicit memory impairments.
  • Sequence learning ability serves as a significant marker for cognitive functioning in children with CP.
  • Abnormal development of frontostriatal and parietal white matter connections may underlie these observed sequence learning difficulties.