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Related Experiment Video

Updated: Jun 4, 2026

Excitotoxic Stimulation of Brain Microslices as an In vitro Model of Stroke

Excitotoxic Stimulation of Brain Microslices as an In vitro Model of Stroke

Published on: February 4, 2014

Stroke intervention pathways: NMDA receptors and beyond.

Ted Weita Lai¹, Woei-Cherng Shyu, Yu Tian Wang

¹Brain Research Centre and Department of Medicine, University of British Columbia, Vancouver, Canada, V6T 2B5.

Trends in Molecular Medicine

|February 12, 2011

Summary

New research explores N-methyl-D-aspartate receptors (NMDARs) in stroke. Understanding specific NMDAR pathways offers hope for developing effective neuroprotective stroke therapies with fewer side effects.

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Published on: July 10, 2018

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Last Updated: Jun 4, 2026

Excitotoxic Stimulation of Brain Microslices as an In vitro Model of Stroke

Excitotoxic Stimulation of Brain Microslices as an In vitro Model of Stroke

Published on: February 4, 2014

A High-throughput Calcium-flux Assay to Study NMDA-receptors with Sensitivity to Glycine/D-serine and Glutamate

A High-throughput Calcium-flux Assay to Study NMDA-receptors with Sensitivity to Glycine/D-serine and Glutamate

Published on: July 10, 2018

Area of Science:

Neuroscience
Pharmacology
Stroke Research

Background:

Excessive N-methyl-D-aspartate receptor (NMDAR) stimulation is linked to brain damage after stroke.
Previous clinical trials targeting NMDARs for stroke have been unsuccessful.

Purpose of the Study:

To review recent advancements in understanding NMDAR subpopulations and downstream effectors in stroke.
To highlight novel targets for developing improved NMDAR-based neuroprotective stroke therapies.

Main Methods:

Review of preclinical and clinical research on NMDARs in stroke.
Analysis of signaling pathways downstream of NMDARs involved in neuronal survival and death.

Main Results:

Identification of distinct NMDAR subpopulations with differential roles in neuronal fate.
Discovery of specific downstream signaling effectors mediating NMDAR-induced neurotoxicity or neuroprotection.

Conclusions:

Novel signaling pathways downstream of NMDARs present promising therapeutic targets for stroke.
Future stroke therapies may leverage specific NMDAR modulation for enhanced efficacy and reduced side effects.