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Neonatal citrobacter sepsis: clinical and epidemiological aspects
G G Christo1, J Mathai, B Nalini
1Department of Pediatrics, Kasturba Medical College and Hospital, Manipal.
Indian Journal of Pediatrics
|November 1, 1990
Summary
Citrobacter sepsis in neonates is a significant concern, particularly for low birth weight and preterm infants. This infection presents with multisystem involvement and high fatality, necessitating strict control measures.
Area of Science:
- Neonatal Medicine
- Infectious Diseases
- Microbiology
Background:
- Citrobacter sepsis is a serious infection in newborns.
- Neonates, especially those with low birth weight and prematurity, are particularly vulnerable.
Purpose of the Study:
- To analyze the incidence, clinical features, and outcomes of Citrobacter sepsis in neonates.
- To highlight the epidemiological characteristics and antibiotic resistance patterns of Citrobacter species in this population.
Main Methods:
- Retrospective review of neonatal cases diagnosed with Citrobacter sepsis between 1986-1989.
- Analysis of clinical data, hematological profiles, infection sites, and treatment outcomes.
Main Results:
- Fourteen cases of Citrobacter sepsis were identified (4.6% of proven sepsis).
- Affected infants were predominantly low birth weight (mean 2046g) and preterm (mean 34.8 weeks), with sepsis onset at a mean of 5 days.
- Multisystem infections, including septic arthritis and meningitis, were observed. The case fatality rate was high at 61%, with frequent antibiotic resistance.
Conclusions:
- Citrobacter sepsis poses a significant threat to neonates, characterized by high mortality and frequent antibiotic resistance.
- The organism's epidemiological features and virulence underscore the need for heightened vigilance and stringent infection control protocols in neonatal intensive care units.