[Morphogenesis of Far Eastern tick-borne encephalitis]

Based on their findings and the data available in the literature, the authors provide the current interpretation of tickborne encephalitis (TBE) in terms of the immunopathological essence of inflammation. The pathomorphological pattern of the central nervous system is shown to reflect the hyperergic nature of inflammation in TBE. The progressive development of the immediate hypersensitivity reactions initiated by the damaging action of the virus on brain tissue and the delayed hypersensitivity ones that provide the formation of local (tissue) immunity. Integrated assessment of human and experimental TBE-induced pathology has established the variability in its manifestations, which depends on the properties of an initiating virus strain, the type of the body's virus-induced immune response, and the stage of morphogenesis of the disease. On this basis, the authors identified 3 clinical and morphological variants of manifestation of an infectious process in TBE.