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[The relationship between the CT signs and p53 abnormal expression in peripheral lung cancer]
Xiaojie Liu1, Weixing Zhang, Guifen Gao
1Image Department, The Third Hospital, Harbin Medical University, Harbin, Heilongjiang 150040, P.R.China.
Background:
To evaluate the relationship between the CT signs and p53 protein abnormal expression in peripheral lung cancer.
Methods:
Fifty-two patients with pulmonary masses underwent CT scanning before operation. Immunohistochemistry was used to detect p53 protein expression in pulmonary specimens obtained by operation.
Results:
There were significant differences among p53 protein expression and differentiation of lung cancer cell, size of the cancer, tumor appearance, pleura excavation and lymphatic metastasis.
Conclusions:
p53 gene mutation indicates the biological behavior of lung cancer and might influence the morphological feature of lung cancer, which remarkably relates to CT signs of lung cancer.
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