Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Heart Valves01:16

Heart Valves

The human heart is a complex organ with an intricate system of valves that regulate blood flow. There are two main types of valves: atrioventricular (AV) valves and semilunar valves.
The AV valves prevent the backflow of blood from the ventricles to the atria during ventricular contraction. These valves function with the assistance of the chordae tendineae and papillary muscles. When the ventricles are relaxed, the chordae tendineae are slack, allowing blood to flow from the atria into the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Endogenous tissue restoration in a hemodialysis conduit: Performance and safety after 1-year of follow-up.

The journal of vascular access·2025
Same author

The First International Consortium for Health Outcomes Measurement (ICHOM) Standard Dataset for Reporting Outcomes in Heart Valve Disease: Moving From Device- to Patient-Centered Outcomes: Developed by a multisociety taskforce coordinated by the Heart Valve Society (HVS) including the American Heart Association (AHA), the American College of Cardiology (ACC), the European Association for Cardio-Thoracic Surgery (EACTS), the European Society of Cardiology (ESC), The Society of Thoracic Surgeons (STS), the Australian & New Zealand Society of Cardiac & Thoracic Surgeons (ANZSCTS), the International Society for Applied Cardiovascular Biology (ISACB), the International Society for Minimally Invasive Cardiothoracic Surgery (ISMICS), the South African Heart Association (SHA), Heart Valve Voice, and Global Heart Hub.

Annals of thoracic surgery short reports·2025
Same author

The First International Consortium for Health Outcomes Measurement (ICHOM) Standard Dataset for Reporting Outcomes in Heart Valve Disease: Moving From Device- to Patient-Centered Outcomes.

Innovations (Philadelphia, Pa.)·2025
Same author

The First International Consortium for Health Outcomes Measurement (ICHOM) Standard Dataset for Reporting Outcomes in Heart Valve Disease: Moving From Device- to Patient-Centered Outcomes: Developed by a multisociety taskforce coordinated by the Heart Valve Society (HVS) including the American Heart Association (AHA), the American College of Cardiology (ACC), the European Association for Cardio-Thoracic Surgery (EACTS), the European Society of Cardiology (ESC), The Society of Thoracic Surgeons (STS), the Australian & New Zealand Society of Cardiac & Thoracic Surgeons (ANZSCTS), the International Society for Applied Cardiovascular Biology (ISACB), the International Society for Minimally Invasive Cardiothoracic Surgery (ISMICS), the South African Heart Association (SHA), Heart Valve Voice, and Global Heart Hub.

JACC. Advances·2025
Same author

The First International Consortium for Health Outcomes Measurement (ICHOM) Standard Dataset for Reporting Outcomes in Heart Valve Disease: Moving From Device- to Patient-Centered Outcomes: Developed by a multisociety taskforce coordinated by the Heart Valve Society (HVS) including the American Heart Association (AHA), the American College of Cardiology (ACC), the European Association for Cardio-Thoracic Surgery (EACTS), the European Society of Cardiology (ESC), The Society of Thoracic Surgeons (STS), the Australian & New Zealand Society of Cardiac & Thoracic Surgeons (ANZSCTS), the International Society for Applied Cardiovascular Biology (ISACB), the International Society for Minimally Invasive Cardiothoracic Surgery (ISMICS), the South African Heart Association (SHA), Heart Valve Voice, and Global Heart Hub.

Circulation. Cardiovascular quality and outcomes·2025
Same author

The first International Consortium for Health Outcomes Measurement (ICHOM) standard dataset for reporting outcomes in heart valve disease: moving from device- to patient- centered outcomes.

European heart journal. Quality of care & clinical outcomes·2025
Same journal

Upcycling food processing byproducts via advanced yeast fermentation.

Current opinion in biotechnology·2026
Same journal

Microbial C1 assimilation pathways for chemical synthesis: from native metabolism to synthetic design.

Current opinion in biotechnology·2026
Same journal

Medicinal plants fermentation: current knowledge and perspectives.

Current opinion in biotechnology·2026
Same journal

Fermented foods: lessons learned from metagenomics.

Current opinion in biotechnology·2026
Same journal

Microfluidic platforms for the transient transfection of mammalian cells: recent developments and challenges.

Current opinion in biotechnology·2026
Same journal

Harvesting insights from recent advances in yeast genomics for predictable and precision wine fermentation.

Current opinion in biotechnology·2026
See all related articles

Related Experiment Video

Updated: Jun 4, 2026

A Multi-Cue Bioreactor to Evaluate the Inflammatory and Regenerative Capacity of Biomaterials under Flow and Stretch
07:51

A Multi-Cue Bioreactor to Evaluate the Inflammatory and Regenerative Capacity of Biomaterials under Flow and Stretch

Published on: December 10, 2020

Heart valve tissue engineering: quo vadis?

Frederick J Schoen1

  • 1Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. fschoen@partners.org

Current Opinion in Biotechnology
|February 15, 2011
PubMed
Summary
This summary is machine-generated.

Tissue engineered heart valves offer a promising solution for pediatric patients, addressing the growth limitations of current prostheses. This review explores the field, highlighting design criteria and challenges for clinical use.

More Related Videos

Transplantation of Pulmonary Valve Using a Mouse Model of Heterotopic Heart Transplantation
10:56

Transplantation of Pulmonary Valve Using a Mouse Model of Heterotopic Heart Transplantation

Published on: July 23, 2014

Combining 3D-Printing and Electrospinning to Manufacture Biomimetic Heart Valve Leaflets
10:29

Combining 3D-Printing and Electrospinning to Manufacture Biomimetic Heart Valve Leaflets

Published on: March 23, 2022

Related Experiment Videos

Last Updated: Jun 4, 2026

A Multi-Cue Bioreactor to Evaluate the Inflammatory and Regenerative Capacity of Biomaterials under Flow and Stretch
07:51

A Multi-Cue Bioreactor to Evaluate the Inflammatory and Regenerative Capacity of Biomaterials under Flow and Stretch

Published on: December 10, 2020

Transplantation of Pulmonary Valve Using a Mouse Model of Heterotopic Heart Transplantation
10:56

Transplantation of Pulmonary Valve Using a Mouse Model of Heterotopic Heart Transplantation

Published on: July 23, 2014

Combining 3D-Printing and Electrospinning to Manufacture Biomimetic Heart Valve Leaflets
10:29

Combining 3D-Printing and Electrospinning to Manufacture Biomimetic Heart Valve Leaflets

Published on: March 23, 2022

Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Cardiovascular Research

Background:

  • Current heart valve replacements (mechanical and tissue) have limitations, particularly in pediatric patients who require valves that can grow, repair, and remodel.
  • Existing prostheses fail to accommodate somatic growth, leading to complications and the need for reoperations in children.

Purpose of the Study:

  • To provide an overview of the field of tissue engineered heart valve technology.
  • To discuss recent advancements, evolving concepts, and design criteria for developing functional engineered heart valves.
  • To identify key challenges that must be overcome for the clinical implementation of tissue engineered heart valves.

Main Methods:

  • Literature review focusing on recent studies in heart valve tissue engineering.
  • Analysis of evolving concepts and design principles for engineered heart valves.
  • Identification of hurdles for clinical translation.

Main Results:

  • Tissue engineering presents a potential solution for pediatric heart valve replacement, offering valves that can grow and remodel.
  • Significant progress has been made in understanding the design criteria for functional engineered heart valves.
  • Several key hurdles remain before clinical implementation, including long-term durability and integration.

Conclusions:

  • Tissue engineered heart valves hold significant promise for addressing the limitations of current prostheses in pediatric patients.
  • Further research and development are necessary to overcome existing challenges and enable clinical application.
  • The field is advancing towards creating living, functional heart valves that can adapt to patient growth.