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Infection of Primary Nasal Epithelial Cells Grown at an Air-Liquid Interface to Characterize Human Coronavirus-Host Interactions
Published on: September 22, 2023
Health care-acquired viral respiratory diseases
William P Goins1, H Keipp Talbot, Thomas R Talbot
1Division of Infectious Diseases, Department of Medicine, Baylor College of Medicine, 1709 Dryden Road, BCM 620, Suite 6.15, Houston, TX 77030, USA.
Insights
Healthcare-associated viral respiratory infections like Respiratory Syncytial Virus (RSV) and influenza increase patient illness and costs. This article reviews the epidemiology, transmission, and control of these common hospital-acquired infections.
Area of Science:
- Infectious Diseases
- Public Health
- Hospital Epidemiology
Background:
- Viral respiratory infections are common in healthcare settings, affecting hospitalized children, adults, and institutionalized individuals.
- These infections contribute significantly to patient morbidity, mortality, and increased healthcare expenditures.
- Approximately 20% of healthcare-associated pneumonia cases involve viral pathogens, with Adenovirus, Influenza virus, Parainfluenza virus, and Respiratory Syncytial Virus (RSV) being the most frequent culprits.
Purpose of the Study:
- To provide a comprehensive overview of the epidemiology, transmission dynamics, and control strategies for healthcare-associated Respiratory Syncytial Virus (RSV) and influenza virus infections.
Main Methods:
- Review of existing literature on healthcare-associated viral respiratory infections.
- Analysis of epidemiological data regarding the prevalence and causative agents.
- Synthesis of information on transmission routes and preventative measures.
Main Results:
- Healthcare-associated viral respiratory infections mirror community viral activity levels.
- Respiratory Syncytial Virus (RSV) and influenza virus are significant pathogens in nosocomial respiratory infections.
- Understanding transmission is key to implementing effective control measures.
Conclusions:
- Effective control of healthcare-associated RSV and influenza requires a multi-faceted approach addressing epidemiology and transmission.
- Public health strategies and hospital infection control practices are crucial for mitigating the impact of these infections.
- Further research into optimal prevention and management strategies is warranted.
Abstract:
Health care-associated viral respiratory infections, common among hospitalized children, also occur among adults and institutionalized persons and result in increased patient morbidity, mortality, and health care costs. Approximately 20% of patients with healthcare-associated pneumonia have viral respiratory infections, with 70% of these infections caused by adenovirus, influenza virus, parainfluenza virus, and respiratory syncytial virus (RSV). These infections typically reflect the level of viral activity within the community. This article focuses on the epidemiology, transmission, and control of health care-associated RSV and influenza virus.
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