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Updated: Jun 4, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
Published on: August 30, 2018
Antimicrobial stewardship
Pranita D Tamma1, Sara E Cosgrove
1Department of Pediatric Infectious Diseases, The Johns Hopkins Medical Institution, 200 North Wolfe Street Suite 3095, Baltimore, MD 21287, USA. ptamma1@jhmi.edu
Abstract:
The overuse and misuse of antimicrobial agents has detrimental effects on patients, the health care system, and society. Inappropriate antimicrobial use contributes to the rising cost of health care, the emergence of multidrug resistant organisms, and adverse drug reactions. Antimicrobial stewardship programs provide standard, evidence-based approaches to encourage judicious use of antimicrobial agents. This review summarizes the goals of antimicrobial stewardship programs, the members needed to initiate and sustain them, antimicrobial stewardship strategies, barriers to the implementation and maintenance of the programs, approaches to measure their effects, and the basic steps needed to initiate them.
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