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Preparing a Mice Model of Severe Acute Pancreatitis via a Combination of Caerulein and Lipopolysaccharide Intraperitoneal Injection
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[Severe and acute pancreatitis admitted in intensive care: a prospective epidemiological multiple centre study using
1Département d'anesthésie-réanimation Saint-Éloi, CHU de Montpellier, 80 avenue Augustin-Fliche, Montpellier, France.
Annales Francaises D'Anesthesie Et De Reanimation
|February 15, 2011
Summary
Severe acute pancreatitis is a significant cause of intensive care unit (ICU) admissions, frequently leading to hospital-acquired infections and high mortality rates, particularly in mechanically ventilated patients.
Area of Science:
- Critical Care Medicine
- Infectious Diseases
- Gastroenterology
Context:
- Severe acute pancreatitis accounts for 2% of intensive care unit (ICU) stays exceeding 48 hours.
- This study analyzed data from 65 centers within the CClin Sud-Est nosocomial infections surveillance network.
- Focuses on patients with severe acute pancreatitis requiring ICU admission for over 48 hours.
Purpose:
- To characterize demographic profiles of severe acute pancreatitis patients in the ICU.
- To determine the incidence of extra-abdominal hospital-acquired infections in this patient cohort.
- To describe the clinical outcomes, including mortality, associated with severe acute pancreatitis in the ICU.
Summary:
- A multi-center analysis of 510 patients with severe acute pancreatitis revealed a 23% overall incidence of hospital-acquired infections.
- Mechanically ventilated patients experienced a higher infection rate (33%) and mortality (34%).
- Severe acute pancreatitis is linked to substantial ICU morbidity and mortality.
Impact:
- Highlights the high burden of hospital-acquired infections in severe acute pancreatitis patients.
- Provides crucial data for sample size calculations in future therapeutic intervention studies.
- Underscores the need for infection prevention strategies in critically ill pancreatitis patients.
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