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Yeast As a Chassis for Developing Functional Assays to Study Human P53
14:57

Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

New plays in the p53 theater

Yael Aylon1, Moshe Oren

  • 1Department of Molecular Cell Biology, The Weizmann Institute of Science, PO Box 26, Rechovot 76100, Israel.

Current Opinion in Genetics & Development
|February 15, 2011
PubMed

Insights

The p53 tumor suppressor network, including p53, p63, and p73, regulates cellular responses to prevent tumors. These proteins act as transcription factors, influencing gene expression and RNA processing to inhibit cancer progression and invasion.

Area of Science:

  • Molecular Biology
  • Cancer Research
  • Genetics

Background:

  • The p53 protein family (p53, p63, p73) plays a critical role in tumor suppression.
  • These proteins function as transcription factors, regulating gene expression and RNA processing.
  • Emerging evidence highlights their involvement in non-canonical pathways beyond traditional tumor suppression.

Purpose of the Study:

  • To elucidate the multifaceted roles of the p53 network in cellular responses to tumorigenic stress.
  • To explore the non-canonical functions of p53, p63, and p73 in cellular processes.
  • To underscore the ongoing discoveries and complexity of the p53 tumor suppressor network.

Main Methods:

  • Review and synthesis of current literature on p53, p63, and p73 functions.
  • Analysis of gene expression data related to p53 targets.
  • Investigation of p53's role in RNA regulation and processing.

Main Results:

  • The p53 network modulates cellular responses against tumorigenic events.
  • p53 and its paralogs are involved in regulating both coding and non-coding RNAs.
  • p53 and p63 demonstrate anti-tumorigenic functions by restricting tumor cell invasion.
  • Non-canonical target genes regulated by p53 impact diverse cellular functions, including metabolism and stem cell renewal.

Conclusions:

  • The p53 network is a complex regulator of cellular responses with critical roles in tumor suppression.
  • Beyond its canonical functions, p53 influences a wide array of cellular processes through non-canonical targets.
  • The full scope of p53's functions in cancer and cellular biology is still under active investigation.

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