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Updated: Jun 4, 2026

An In vitro System to Gauge the Thrombolytic Efficacy of Histotripsy and a Lytic Drug
Published on: June 4, 2021
The persistent thrombus: complications, diagnosis, and novel treatment intervention
John Moua1, Eliezer Nussbaum, Yong-son Kim
1Miller Children's Hospital, Long Beach, CA, USA.
Objective:
To review the findings and discuss the implications of the topic of pharmacomechanical thrombolysis in pediatric patients with persistent thrombus.
Design:
A pediatric case presentation with a brief literature review on treatment of venous thrombosis and pharmacomechanical thrombolysis.
Interventions:
None.
Main Results:
Thrombotic events refractory to standard medical and surgical care remain a life-threatening clinical challenge in the pediatric population. Research on persistent deep venous thrombosis and treatment modalities is limited. We present a pediatric patient with a history of malignant osteosarcoma who was diagnosed with deep venous thrombosis. Despite appropriate anticoagulation therapy, the thrombus remained persistent. Pharmacomechanical thrombolysis was utilized and proved to be an effective method in providing diagnosis and treatment.
Conclusion:
Pharmacomechanical thrombolysis is a valuable and effective method in providing diagnosis and treatment of persistent thrombus.
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