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A Double Humanized BLT-mice Model Featuring a Stable Human-Like Gut Microbiome and Human Immune System
Published on: August 30, 2019
Murine animal model
N Nishisaka1, P Morse, R F Jones
1Department of Urology, State University of New York Health Science Center at Syracuse and VA Medical Center, Syracuse, NY.
Abstract:
Experimental animal models are available for the development of new treatment. Murine animal models have particular advantages for comparative study to evaluate the efficacy and safety of different treatment modalities because many mice can be treated at the same time with easy handling. Among several experimental models, murine renal carcinoma (Renca), which arises spontaneously in Balb/c mice, is the most frequently used for the assessment of chemotherapy, immunotherapy, and radiotherapy. Renca cells readily establish tumors in isogenic mice, producing histologically proven adenocarcinoma with a predictable growth rate to mimic the clinical situation for orthotopic growth and metastasis in a reasonable time frame. Because of its poor immunogenicity and its responsiveness to immunotherapy, the number of studies using cytokine gene-modified tumor vaccines-such as interferon-alpha or interleukin-2-in the Renca system is growing. Therefore, Renca experiments greatly contribute to the analysis of the mechanisms of antitumor immune response. In this chapter, we describe several experimental systems using this Renca model.
Insights
The Renca murine model offers a valuable platform for studying renal carcinoma treatments. This model facilitates research into chemotherapy, immunotherapy, and radiotherapy efficacy and safety in mice.
Area of Science:
- Oncology
- Immunology
- Animal Models
Background:
- Murine models are advantageous for evaluating treatment efficacy and safety due to ease of handling and scalability.
- The Renca (renal carcinoma) model in Balb/c mice is frequently utilized for preclinical cancer research.
- Renca cells form orthotopic tumors with predictable growth, mimicking clinical renal adenocarcinoma and metastasis.
Purpose of the Study:
- To describe experimental systems utilizing the Renca murine model for cancer research.
- To highlight the utility of the Renca model in assessing chemotherapy, immunotherapy, and radiotherapy.
- To emphasize the Renca model's contribution to understanding antitumor immune responses.
Main Methods:
- Utilizing spontaneous murine renal carcinoma (Renca) in Balb/c mice.
- Establishing orthotopic tumors for assessment of treatment modalities.
- Employing cytokine gene-modified tumor vaccines (e.g., interferon-alpha, interleukin-2).
Main Results:
- Renca model provides histologically proven adenocarcinoma with predictable growth rates.
- The model supports the evaluation of chemotherapy, immunotherapy, and radiotherapy.
- Growing use of Renca for immunotherapy studies, particularly with cytokine gene modification.
Conclusions:
- The Renca murine model is a robust system for preclinical evaluation of renal carcinoma treatments.
- This model aids in analyzing antitumor immune response mechanisms.
- Renca experiments are crucial for advancing cancer therapy research.
