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Related Experiment Videos

In vitro variability in fentanyl absorption by different membrane oxygenators.

D A Rosen1, K R Rosen, D L Silvasi

  • 1Department of Anesthesiology, University of Michigan Medical Center, C.S. Mott Children's Hospital, Ann Arbor 48109.

Journal of Cardiothoracic Anesthesia
|June 1, 1990
PubMed
Summary

The SciMed silicone membrane oxygenator demonstrated superior fentanyl uptake compared to polypropylene types. This finding is crucial for understanding drug interactions during cardiopulmonary bypass.

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Area of Science:

  • Biomedical Engineering
  • Pharmacology

Background:

  • Membrane oxygenators are widely used in clinical settings, replacing bubble oxygenators.
  • These devices are categorized into silicone (true membrane), microporous polypropylene sheet, and microtubular polypropylene structures.

Purpose of the Study:

  • To evaluate and compare the in vitro fentanyl uptake capacity of three distinct membrane oxygenator designs.
  • To determine the influence of membrane composition and structure on drug binding.

Main Methods:

  • In vitro incubation of membrane samples (silicone, microporous polypropylene, microtubular polypropylene) with tritiated fentanyl in Normosol-R at pH 7.4 and 37°C.
  • Quantification of fentanyl uptake using liquid scintillation and radioimmunoassay techniques across various drug concentrations (10-340 ng/mL).

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Main Results:

  • The silicone membrane oxygenator (SciMed, type 1) exhibited the highest fentanyl binding capacity (130 ng/cm²).
  • Microporous polypropylene oxygenators (Shiley, Omnis - type 2) showed significantly lower uptake (0.1-11 ng/cm²).
  • Microtubular polypropylene oxygenators (Bentley, Terumo - type 3) demonstrated negligible fentanyl absorption.

Conclusions:

  • Silicone membrane oxygenators possess a greater capacity for fentanyl uptake than polypropylene-based devices.
  • Membrane composition and structure significantly influence drug binding characteristics of oxygenators.
  • These findings have implications for managing drug administration during procedures utilizing cardiopulmonary bypass.