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Inhibition of tumor blood flow

C Lai-Ming1, W R Wilson, B C Baguley

  • 1Cancer Research Laboratory, University of Auckland School of Medicine, Auckland, New Zealand.

Methods in Molecular Medicine
|February 15, 2011
PubMed

Insights

Tumor blood vessel development is disorganized, offering a potential target for cancer therapy. This review explores methods to inhibit tumor blood flow and measure its impact.

Area of Science:

  • Oncology
  • Vascular Biology

Background:

  • Cancer research historically sought universal biochemical targets.
  • Genetic heterogeneity of individual tumors is now recognized.
  • Disorganized tumor vasculature is a common feature across solid tumors.

Purpose of the Study:

  • To review the vasculature of solid tumors.
  • To describe methods for inhibiting tumor blood flow.
  • To review methods for measuring tumor blood flow.

Main Methods:

  • Review of existing literature on tumor vasculature.
  • Description of anti-angiogenic drug strategies.
  • Overview of techniques for assessing tumor hemodynamics.

Main Results:

  • Tumor capillaries exhibit haphazard structure and dynamics compared to normal tissue.
  • Inhibiting tumor blood flow presents a viable therapeutic strategy.
  • Various methods exist for quantifying tumor blood flow.

Conclusions:

  • The unique vascularization of solid tumors provides a potential therapeutic target.
  • Targeting tumor angiogenesis may offer selective cancer treatment.
  • Accurate measurement of tumor blood flow is crucial for evaluating treatment efficacy.

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