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Time dependent changes in aortic tissue during cold storage in physiological solution.

M G Ghosn1, M Mashiatulla, M A Mohamed

  • 1Department of Biomedical Engineering, University of Houston, Houston, TX 77204, USA.

Biochimica Et Biophysica Acta
|February 16, 2011
PubMed
Summary
This summary is machine-generated.

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Aortic tissue stored at 4°C shows significant changes in permeability and pore size after 10 days. Optical coherence tomography (OCT) effectively monitors this loss of structural integrity over time.

Area of Science:

  • Biomedical Engineering
  • Vascular Biology
  • Medical Imaging

Background:

  • Stored vascular tissues are crucial for biomedical research, including imaging, biomechanics, and disease assessment.
  • Understanding the stability of stored aortic tissue is essential for reliable experimental outcomes.

Purpose of the Study:

  • To monitor the stability of aortic tissue stored in phosphate-buffered saline (PBS) at 4°C over 10 days.
  • To evaluate the efficacy of optical coherence tomography (OCT) in assessing tissue structural integrity.

Main Methods:

  • Glucose permeation rates were measured using OCT.
  • Histology was employed to quantify changes in tissue pore area.
  • Statistical analysis (z-test) was used to determine significant changes in permeability.

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Main Results:

  • Aortic tissue permeability increased by nearly 300% after 10 days of storage at 4°C.
  • Significant changes in permeability were observed after just 4 days of storage (p<0.05).
  • Increased pore area correlated with increased permeability, indicating a loss of structural integrity.

Conclusions:

  • Aortic tissue retains structural integrity for at least three days when stored at 4°C.
  • OCT is a powerful, non-invasive tool for evaluating the structural integrity of stored aortic tissue.
  • OCT can be used to assess the effectiveness of different tissue preservation methods.