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Epstein-Barr virus infection as a cause of cervical lymphadenopathy in children

Mosaad Abdel-Aziz1, Hassan El-Hoshy, Mohammed Rashed

  • 1Department of Otolaryngology, Faculty of Medicine, Cairo University, Egypt. mosabeez@yahoo.com

International Journal of Pediatric Otorhinolaryngology
|February 16, 2011
PubMed

Insights

Epstein-Barr virus (EBV) infection is a common cause of cervical lymphadenopathy in children. Posterior cervical lymph node enlargement may indicate EBV, often accompanied by fever and tonsillitis.

Area of Science:

  • Pediatric Infectious Diseases
  • Virology

Background:

  • Cervical lymphadenopathy is a frequent pediatric concern with diverse differential diagnoses.
  • Epstein-Barr virus (EBV) is a significant pathogen in childhood infections.

Purpose of the Study:

  • To determine the prevalence of EBV infection in children with cervical lymphadenopathy.
  • To correlate clinical manifestations with EBV infection in pediatric patients.

Main Methods:

  • Serological testing for EBV (heterophile antibodies, VCA-IgM, VCA-IgG) was performed on 160 children with cervical lymphadenopathy.
  • Clinical evaluations were conducted on EBV-positive cases to document disease manifestations.

Main Results:

  • EBV serology was positive in 15% (24/160) of cases.
  • Posterior cervical lymphadenopathy was present in all EBV-positive children.
  • Common clinical signs included fever (70.8%), tonsillo-pharyngitis (66.6%), and splenomegaly (58.3%).

Conclusions:

  • EBV infection is a notable cause of pediatric cervical lymphadenopathy.
  • Posterior cervical lymphadenopathy can be a key indicator for suspecting EBV in children.
  • Associated symptoms like hepato-splenomegaly, rash, and palatal petechiae aid in diagnosis.
Abstract

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