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A premenopausal woman with virilization secondary to an ovarian Leydig cell tumor
André M Faria1, Ricardo V Perez, José A M Marcondes
1Department of Endocrinology, University of São Paulo Medical School, Cerqueira César 05403-000, São Paulo, Brazil. andremfaria@ hotmail.com
Background:
A 33-year-old woman presented to an endocrinology clinic with a 5-year history of secondary amenorrhea. 2 years before presentation, she had noticed progressively worsening signs of virilization.
Investigations:
Measurement of levels of serum free and total testosterone, androstenedione, dehydroepiandrosterone sulfate and gonadotropins; transvaginal ultrasonography, abdominal and pelvic MRI and (18)F-fluorodeoxyglucose PET imaging.
Diagnosis:
Virilization secondary to an ovarian Leydig cell tumor.
Management:
The patient underwent a left salpingo-oophorectomy that confirmed the diagnosis of a unilateral Leydig cell tumor. Complete normalization of androgens and gonadotropin levels was achieved after surgery.
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