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Related Concept Videos

Inheritance of Chromatin Structures03:17

Inheritance of Chromatin Structures

Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying DNA...
Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
Inheritance01:25

Inheritance

Gregor Mendel's pioneering work on the principles of inheritance fundamentally transformed our understanding of how traits are transmitted from generation to generation. His experiments with pea plants laid the groundwork for the discovery of genes, discrete units within organisms that control heredity.
Each gene exists in pairs, and the combination of these genes from both parents forms an individual's genotype. This genotype is a blueprint of potential traits. Examples of genotype traits...
Non-nuclear Inheritance01:29

Non-nuclear Inheritance

Most DNA resides in the nucleus of a cell. However, some organelles in the cell cytoplasm⁠—such as chloroplasts and mitochondria⁠—also have their own DNA. These organelles replicate their DNA independently of the nuclear DNA of the cell in which they reside. Non-nuclear inheritance describes the inheritance of genes from structures other than the nucleus.
Non-nuclear Inheritance01:29

Non-nuclear Inheritance

Most DNA resides in the nucleus of a cell. However, some organelles in the cell cytoplasm⁠—such as chloroplasts and mitochondria⁠—also have their own DNA. These organelles replicate their DNA independently of the nuclear DNA of the cell in which they reside. Non-nuclear inheritance describes the inheritance of genes from structures other than the nucleus.
Chromosomal Theory of Inheritance01:39

Chromosomal Theory of Inheritance

In 1866, Gregor Mendel published the results of his pea plant breeding experiments, providing evidence for predictable patterns in the inheritance of physical characteristics. The significance of his findings was not immediately recognized. In fact, the existence of genes was unknown at the time. Mendel referred to hereditary units as “factors.”

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Related Experiment Video

Updated: Jun 4, 2026

Analysis of Transgenerational Epigenetic Inheritance in C. elegans Using a Fluorescent Reporter and Chromatin Immunoprecipitation (ChIP)
10:28

Analysis of Transgenerational Epigenetic Inheritance in C. elegans Using a Fluorescent Reporter and Chromatin Immunoprecipitation (ChIP)

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Epigenetic inheritance: uncontested?

Bing Zhu1, Danny Reinberg

  • 1National Institute of Biological Sciences, Beijing 102206, China. zhubing@nibs.ac.cn

Cell Research
|February 16, 2011
PubMed
Summary
This summary is machine-generated.

Epigenetics involves inheriting traits without DNA sequence changes. This review explores how histone modifications are inherited during cell division, advancing our understanding of epigenetic inheritance.

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High-throughput Screening for Protein-based Inheritance in S. cerevisiae
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Last Updated: Jun 4, 2026

Analysis of Transgenerational Epigenetic Inheritance in C. elegans Using a Fluorescent Reporter and Chromatin Immunoprecipitation (ChIP)
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High-throughput Screening for Protein-based Inheritance in S. cerevisiae
08:12

High-throughput Screening for Protein-based Inheritance in S. cerevisiae

Published on: August 8, 2017

Area of Science:

  • Molecular Biology
  • Genetics
  • Epigenetics

Background:

  • Epigenetics is defined as heritable changes in gene expression not caused by DNA sequence alterations.
  • Histones are crucial for carrying epigenetic information, yet the mechanisms of their inheritance remain largely unknown.
  • Understanding histone modification and variant inheritance is key to comprehending epigenetic memory.

Purpose of the Study:

  • To review recent advancements in the field of epigenetic inheritance.
  • To discuss potential models for the mitotic inheritance of histone modifications.
  • To elucidate the molecular mechanisms underlying the transmission of histone-based epigenetic information.

Main Methods:

  • Literature review of recent studies on histone modification inheritance.
  • Analysis of proposed models for epigenetic information transmission during mitosis.
  • Discussion of experimental evidence supporting various inheritance mechanisms.

Main Results:

  • Histone modifications and variants are key carriers of epigenetic information.
  • Several models are proposed for the faithful inheritance of histone marks through cell division.
  • The precise molecular machinery for this inheritance is still under investigation.

Conclusions:

  • Histone-based epigenetic information plays a critical role in cellular identity and function.
  • Further research is needed to fully elucidate the molecular mechanisms of histone epigenetic inheritance.
  • Understanding these mechanisms has implications for developmental biology and disease.