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Updated: Jun 4, 2026

11:56
Generation of Mice Derived from Induced Pluripotent Stem Cells
Published on: November 29, 2012
iPS cells generated without c-Myc have active Dlk1-Dio3 region and are capable of producing full-term mice through
Cell Research
|February 16, 2011
Abstract
No abstract available in PubMed .
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Reprogramming alters the gene expression in somatic cells, transforming them into induced pluripotent stem (iPS) cells over several generations. Scientists can reprogram cells by introducing genes for four transcription factors—Oct4, Sox2, Klf4, and c-Myc (OSKM) by viral or non-viral methods. These factors are also known as Yamanaka factors after Shinya Yamanaka, who first generated iPS cells using mouse skin cells. Yamanaka was awarded the Nobel Prize in Physiology or Medicine in 2012 for this...
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