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Curcuminoid-Mediated Antimicrobial Photodynamic Therapy on a Murine Model of Oral Candidiasis
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Published on: October 27, 2023

Curcumin nanoparticles: preparation, characterization, and antimicrobial study.

Bhawana1, Rupesh Kumar Basniwal, Harpreet Singh Buttar

  • 1Amity Institute of Advanced Research and Studies, and ‡Amity Institute of Biotechnology, Amity University , Noida, Uttar Pradesh 201 301, India.

Journal of Agricultural and Food Chemistry
|February 17, 2011
PubMed
Summary

Curcumin nanoparticles (nanocurcumin) significantly enhance curcumin's water solubility and antimicrobial activity. Nanocurcumin effectively combats bacteria and fungi by disrupting cell walls, improving upon curcumin's limitations.

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Area of Science:

  • Pharmacology and Nanotechnology
  • Microbiology

Background:

  • Curcumin, a natural compound from turmeric, has potent bioactive properties but suffers from low solubility and bioavailability.
  • Traditional curcumin formulations limit its therapeutic applications due to poor water dispersibility.

Purpose of the Study:

  • To develop curcumin nanoparticles (nanocurcumin) to enhance aqueous solubility and antimicrobial efficacy.
  • To investigate the impact of particle size reduction on curcumin's bioactivity.

Main Methods:

  • Nanocurcumin preparation using a wet-milling technique, yielding particles of 2-40 nm.
  • Determination of minimum inhibitory concentration (MIC) against various bacterial and fungal strains.
  • Mechanism of action investigation using transmission electron microscopy (TEM).

Main Results:

  • Nanocurcumin exhibited excellent water dispersibility without surfactants, unlike native curcumin.
  • Nanocurcumin demonstrated significantly improved antimicrobial activity against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa, Penicillium notatum, and Aspergillus niger.
  • Antimicrobial activity was more potent against Gram-positive bacteria than Gram-negative, and antibacterial effects surpassed antifungal effects.

Conclusions:

  • Particle size reduction to the nano range markedly improves curcumin's water solubility and antimicrobial properties.
  • Nanocurcumin offers a promising approach to overcome curcumin's bioavailability challenges for enhanced therapeutic use.
  • TEM analysis revealed nanocurcumin's mechanism involves cell wall disruption and entry into bacterial cells, leading to cell death.