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Effect of sympathomimetic drugs on canine bladder: surgical model for assessment of regional differences

J W Downie1, S A Awad, D W Lywood

  • 1Department of Urology, Queen's University, Kingston, Ontario, Canada.

Urology
|February 18, 2011
PubMed

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Drugs that mimic the action of endogenous catecholamines like noradrenaline and adrenaline are called adrenergic agonists or sympathomimetics. Based on their mechanism of action, sympathomimetics can be classified as direct-, indirect-, or mixed-acting sympathomimetics. Direct-acting adrenergic agonists activate adrenoceptors without affecting presynaptic neurons, making them independent of neuronal catecholamine-depleting agents like reserpine and guanethidine.
These agents can be classified...