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Extracorporeal treatment of cast nephropathy

Bhavna Gakhar, Sidney Kobrin, Jeffrey S Berns

    Seminars in Dialysis
    |February 18, 2011
    PubMed

    Insights

    Acute kidney injury (AKI) in multiple myeloma (MM) is often caused by free light chains (FLC). Reducing FLC levels with treatments like plasma exchange or high cutoff hemodialysis may aid kidney recovery, but more research is needed.

    Area of Science:

    • Nephrology
    • Oncology
    • Hematology

    Background:

    • Acute kidney injury (AKI) is a frequent complication in multiple myeloma (MM).
    • Cast nephropathy, caused by free light chain (FLC) precipitation in renal tubules, is the primary driver of AKI in MM.
    • AKI in MM is associated with poor prognosis and potential need for dialysis.

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