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Updated: Jun 4, 2026
Optimization of a Multiplex RNA-based Expression Assay Using Breast Cancer Archival Material
Published on: August 1, 2018
[A study on the expression of erbB4/HER4 in non-small cell lung cancer]
Zaichun Deng1, Wenying Yu, Guoping Hu
1Respiratory Department, The Affiliated Hospital, Ningbo University, Ningbo, Zhejiang 315020, P.R.China.
Background:
To detect the expression of human epidermal-growth-factor receptor 4 (HER4) and elucidate the relationship between its overexpression and the clinicopathological characteristics in non-small cell lung cancer (NSCLC).
Methods:
The expression of HER4 was detected in 70 cases of paraffin-embedded NSCLC tissues by immunohistochemical assay.
Results:
HER4 were overexpressed in 91.4% of NSCLC. The overexpression of HER4 was significantly related to lymph node metastasis (P=0.007), TNM stages (P=0.011) and postoperative survival rate (P= 0.0258).
Conclusions:
erbB4 is one of the genes to regulate the growth of advanced NSCLC. The artificial interference with HER4 overexpression may be a good way in the treatment of advanced NSCLC.
