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Updated: Jun 4, 2026

Multidimensional Coculture System to Model Lung Squamous Carcinoma Progression
Published on: March 17, 2020
[Carcinoma of the lung and multiple primary malignant tumors]
Hui Li1, Wei Wang, Liqun Shang
1Department of Thoracic Surgery, General Hospital of Navy, Beijing 100037, P.R.China.
Background:
To evaluate the incidence of multiple primary malignancies combined with lung and other organs and their relationship.
Methods:
All patients who consecutively treated for lung cancer from December 1964 to December 1992, were retrospectively analyzed regarding the recurrence of a synchronous primary tumor elsewhere in the body.
Results:
Of total 1019 patients reviewed, 21 (2.1%) had associated carcinoma of other organs. In these 21 patients, the incidence of associated aerodigestive tract cancer was 71.4% (15/21) and that of other organs was 28.6% (6/21). Five patients had simultaneous cancer with the lung cancer and 16 had metachronous cancer.
Conclusions:
Multiple primary tumors in patients with carcinoma of the lungs is not a rare phenomenon. Surveillance programs for detection of second primary tumors should focus on these patients.
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