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Updated: Jun 4, 2026

Efficient Gene Delivery into Multiple CNS Territories Using In Utero Electroporation
Published on: June 23, 2011
Activation and function of immediate-early genes in the nervous system
Beatriz Pérez-Cadahía1, Bojan Drobic, James R Davie
1Toxicology Unit, Department of Psychobiology, University of A Coruña, A Coruña, Spain.
Abstract:
Immediate-early genes have important roles in processes such as brain development, learning, and responses to drug abuse. Further, immediate-early genes play an essential role in cellular responses that contribute to long-term neuronal plasticity. Neuronal plasticity is a characteristic of the nervous system that is not limited to the first stages of brain development but persists in adulthood and seems to be an inherent feature of everyday brain function. The plasticity refers to the neuron's capability of showing short- or long-lasting phenotypic changes in response to different stimuli and cellular scenarios. In this review, we focus on the immediate-early genes encoding transcription factors (AP-1 and Egr) that are relevant for neuronal responses. Our current understanding of the mechanisms involved in the induction of the immediate-early genes is presented.
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