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Updated: Jun 4, 2026

Oligopeptide Competition Assay for Phosphorylation Site Determination
Published on: May 18, 2017
Crosstalk between phosphorylation and multi-site arginine/lysine methylation in C/EBPs
Achim Leutz1, Ole Pless, Michael Lappe
1Max Delbrueck Center for Molecular Medicine, Berlin, Germany. aleutz@mdc-berlin.de
Abstract:
C/EBPs are implied in an amazing number of cellular functions: C/EBPs regulate tissue and cell type specific gene expression, proliferation, and differentiation control. C/EBPs assist in energy metabolism, female reproduction, innate immunity, inflammation, senescence, and the development of neoplasms. How can C/EBPs fulfill so many functions? Here we discuss that C/EBPs are extensively modified by methylation of arginine and lysine side chains and that regulated methylation profoundly affects the activity of C/EBPs.
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