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Successful photopatch testing with ketoprofen using one-hour occlusion
Victoria Marmgren1, Monica Hindsén, Erik Zimerson
1Department of Occupational and Environmental Dermatology, Skåne University Hospital, Malmö, Lund University, SE-205 02 Malmö, Sweden. victoria.marmgren@vgregion.se
Acta Dermato-Venereologica
|February 18, 2011
Summary
Reducing photopatch testing occlusion time to 1 hour is sufficient for identifying ketoprofen photo-contact allergy. This simplification streamlines the procedure, potentially eliminating an extra clinic visit for patients.
Area of Science:
- Dermatology
- Allergology
- Photobiology
Background:
- Standard photopatch testing involves 24-hour allergen occlusion followed by UVA irradiation.
- This standard procedure necessitates two separate clinic visits, increasing patient burden.
- Simplifying the photopatch testing protocol is desirable to improve patient compliance and clinic efficiency.
Purpose of the Study:
- To evaluate if reducing occlusion time from 24 hours to 1 hour affects photopatch test results for ketoprofen.
- To determine if a shortened occlusion period maintains diagnostic accuracy for ketoprofen photo-contact allergy.
Main Methods:
- A comparative study involving 22 patients with suspected ketoprofen photo-allergy.
- Simultaneous photopatch testing with ketoprofen using both 1-hour and 24-hour occlusion periods.
- Standardized UVA irradiation (5 J/cm2) applied to one side, with the other side serving as a non-irradiated control. Twenty controls were also tested with 1-hour occlusion.
Main Results:
- All 22 patients exhibited positive reactions on the UVA-irradiated sites, regardless of occlusion duration (1h vs 24h).
- No positive reactions were observed on the non-irradiated control sites.
- All 20 control subjects tested with 1-hour occlusion showed negative results.
Conclusions:
- A 1-hour occlusion period is adequate for diagnosing photo-contact allergy to ketoprofen.
- The simplified 1-hour occlusion protocol does not require adjustments to UVA or ketoprofen dosage.
- Shortening occlusion time to 1 hour can significantly simplify the photopatch testing procedure for ketoprofen, potentially reducing the need for an additional clinic visit.
