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An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection
09:01

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Trends in chronologic age and infant respiratory syncytial virus hospitalization: an 8-year cohort study

Jon P Fryzek1, William J Martone, Jessie R Groothuis

  • 1One MedImmune Way, Gaithersburg, MD 20878, USA. GroothuisJ@MedImmune.com

Advances in Therapy
|February 18, 2011
PubMed

Insights

Infants under 6 months, especially those under 3 months, face the highest risk of respiratory syncytial virus (RSV) hospitalization. The 3- to 6-month age group experienced the greatest proportion of RSV hospitalizations.

Area of Science:

  • Pediatric Infectious Diseases
  • Epidemiology
  • Public Health

Background:

  • Respiratory syncytial virus (RSV) is a primary cause of severe respiratory infections in young children.
  • RSV is the leading cause of infant hospitalizations under one year of age.

Purpose of the Study:

  • To analyze trends in RSV hospitalizations (RSVH) among infants in the US from 1998 to 2006.
  • To identify age-specific hospitalization rates and proportions for RSV among infants.

Main Methods:

  • Utilized the US National Hospital Discharge Survey (NHDS) database from 1998-2006.
  • Defined RSVH using ICD-9-CM codes for RSV, RSV-associated bronchiolitis, and pneumonia.
  • Analyzed RSVH rates across infant age cohorts: <3 months, 3-6 months, and >6 to <24 months.

Main Results:

  • Over 1.1 million RSVHs occurred in children under 24 months.
  • Infants <3 months had significantly higher RSVH rates (RR, 7.38) compared to older infants.
  • The 3- to 6-month age group showed the highest proportion of RSV hospitalizations annually (14%-23%).

Conclusions:

  • The highest relative rates of RSVH were observed in infants younger than 6 months.
  • The 3- to 6-month age group accounted for the largest proportion of RSV hospitalizations.
  • Further research is needed to understand factors influencing these RSV hospitalization trends.
Abstract

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