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Related Concept Videos

Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview
Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...

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Related Experiment Video

Updated: Jun 4, 2026

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
18:48

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

Published on: August 12, 2017

Clinical transplantation tolerance.

Kenneth A Newell1

  • 1Department of Surgery and the Emory Transplant Center, Emory University, Atlanta, GA 30322, USA. kanewel@emory.edu

Seminars in Immunopathology
|February 18, 2011
PubMed
Summary
This summary is machine-generated.

Achieving stable transplant tolerance is crucial to avoid immunosuppression side effects. Current research focuses on developing safe methods and biomarkers to make tolerance feasible in clinical transplantation.

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Last Updated: Jun 4, 2026

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
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Area of Science:

  • Immunology
  • Transplant Surgery
  • Clinical Medicine

Background:

  • Organ transplantation is a vital treatment for end-stage organ failure, with over 20,000 procedures annually in the USA.
  • Over 170,000 individuals live with transplants, relying on immunosuppression to maintain organ function.
  • Long-term immunosuppression poses significant risks, including reduced patient and organ survival and diminished quality of life.

Purpose of the Study:

  • To review the current status of research aimed at achieving stable tolerance in clinical transplantation.
  • To identify barriers and ongoing efforts in developing therapeutic regimens and biomarkers for transplantation tolerance.
  • To explore strategies for making clinical transplantation tolerance more feasible and safer for patients.

Main Methods:

  • Review of existing literature and ongoing clinical studies on transplantation tolerance.
  • Analysis of factors limiting the broader investigation of tolerance induction in human transplantation.
  • Examination of safety and ethical considerations regarding immunosuppression withdrawal.

Main Results:

  • Stable tolerance remains an infrequent outcome in clinical transplantation, often occurring by chance.
  • Key barriers include the lack of proven tolerance-inducing regimens, validated predictive biomarkers, and safety concerns regarding immunosuppression withdrawal.
  • Despite challenges, ongoing studies are cautiously progressing with the goal of enhancing tolerance feasibility.

Conclusions:

  • Inducing stable tolerance is essential to mitigate the adverse effects of long-term immunosuppression in transplant recipients.
  • Further research is needed to overcome current limitations and establish reliable methods for achieving transplantation tolerance.
  • Advancing transplantation tolerance could significantly improve long-term outcomes and quality of life for transplant patients.