Cancer incidence and mortality among workers exposed to benzidine.
Shannon Cameron Brown1, Risa Alberts, Mark Schoenberg
1Bladder Cancer Research Center, James Buchanan Brady Urological Institute, John Hopkins Medical Institutions, Baltimore, Maryland, USA. sbrown@jhsph.edu
American Journal of Industrial Medicine
|February 18, 2011
Summary
Occupational exposure to benzidine and arylamines increased cancer risk, particularly bladder cancer. Elevated risks were also observed for small intestine and soft tissue cancers, supporting previous findings.
Area of Science:
- Occupational Health
- Toxicology
- Epidemiology
Background:
- A cohort study involved 997 workers at a chemical production facility.
- Investigated occupational exposure to benzidine and arylamines.
- Examined the association between these exposures and cancer risk.
Purpose of the Study:
- To determine if occupational exposure to benzidine and arylamines increases cancer risk.
- To quantify the risk of specific cancers associated with these exposures.
Main Methods:
- Cancers identified via registries, death certificates, and medical records.
- Job-exposure matrix used to assess exposure levels.
- Standardized incidence ratios (SIRs) and survival analyses performed.
Main Results:
- Elevated SIRs for bladder cancer (SIR=3.5), small intestine cancer (SIR=18.4), and soft tissue cancers (SIR=11.9) in highly exposed workers.
- Cancer risk increased with higher exposure levels.
- Elevated SIRs observed for additional cancer types.
Conclusions:
- Findings confirm increased bladder cancer risk from benzidine and arylamine exposure.
- Suggests elevated risk for cancers beyond bladder cancer in exposed workers.
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