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[Detection of serum total MMP-9 and its clinical significance for lung neoplasms]
Zuofu Xie1, Yunkun Wu, Dongmei Zhou
1Department of Immunopathology, Fujian Provincial Tumor Hospital & Fujian Provincial Cancer Institute, Fuzhou, Fujian 350014, P.R.China.
Background:
To investigate the clinical value of serum total MMP-9 detection in lung malignancies.
Methods:
Serum total MMP-9 levels were detected in 63 patients with lung malignancies by sandwich ELISA with monoclonal antibody against human total MMP-9.
Results:
Serum total MMP-9 was (92.2± 74.39) μg/L in lung malignancy group, which was significantly higher than that of healthy control [(9.5± 6.74) μg/L](P < 0.05). In lung cancer group, there were significant differences in serum total MMP-9 level between patients with and without lymph node metastasis, and between progressive disease+death group and complete response+partial response group. Significantly negative correlation was observed between serum CA242 and serum total MMP-9 levels (P=0.021).
Conclusions:
Detection of serum total MMP-9 may be helpful to predict metastasis and treatment response of lung cancer.
