Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Synaptic Signaling01:12

Synaptic Signaling

Neurons communicate at synapses, or junctions, to excite or inhibit the activity of other neurons or target cells, such as muscles. Synapses may be chemical or electrical.
Synaptic Signaling01:09

Synaptic Signaling

Neurons communicate at synapses, or junctions, to excite or inhibit the activity of other neurons or target cells, such as muscles. Synapses may be chemical or electrical.
Most synapses are chemical, meaning an electrical impulse or action potential spurs the release of chemical messengers called neurotransmitters. The neuron sending the signal is called the presynaptic neuron, and the neuron receiving the signal is the postsynaptic neuron.
The presynaptic neuron fires an action potential that...
Enzyme-linked Receptors01:00

Enzyme-linked Receptors

Enzyme-linked receptors are proteins that act as both receptor and enzyme, activating multiple intracellular signals. This is a large group of receptors that include the receptor tyrosine kinase (RTK) family. Many growth factors and hormones bind to and activate the RTKs.
Neurotrophin (NT) receptors are a family of RTKs, including trkA, trkB, and trkC (tropomyosin-related kinase) receptors. TrkA is specific for nerve growth factor (NGF), neurotrophin-6, and neurotrophin-7. TrkB binds...
Intracellular Signaling Cascades01:24

Intracellular Signaling Cascades

Once a ligand binds to a receptor, the signal is transmitted through the membrane and into the cytoplasm. The continuation of a signal in this manner is called signal transduction. Signal transduction only occurs with cell-surface receptors, which cannot interact with most components of the cell, such as DNA. Only internal receptors can interact directly with DNA in the nucleus to initiate protein synthesis. When a ligand binds to its receptor, conformational changes occur that affect the...
Intracellular Signaling Cascades01:24

Intracellular Signaling Cascades

Once a ligand binds to a receptor, the signal is transmitted through the membrane and into the cytoplasm. The continuation of a signal in this manner is called signal transduction. Signal transduction only occurs with cell-surface receptors, which cannot interact with most components of the cell, such as DNA. Only internal receptors can interact directly with DNA in the nucleus to initiate protein synthesis. When a ligand binds to its receptor, conformational changes occur that affect the...
Assembly of Signaling Complexes01:30

Assembly of Signaling Complexes

Multiprotein signaling complexes are formed in a dynamic process involving protein-protein interactions at the cytoplasmic domain of transmembrane receptors or enzymatic and non-enzymatic proteins associated with the receptor. These complexes ensure the activation and propagation of intracellular signals that regulate cell functions.
Interaction domains in cell signaling
Interaction domains recognize exposed features of their binding partners containing post-translationally modified sequences,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

High-throughput imaging of ATG9A distribution as a diagnostic functional assay for adaptor protein complex 4-associated hereditary spastic paraplegia.

Brain communications·2021
Same author

Neurodevelopmental profile of HIVEP2-related disorder.

Developmental medicine and child neurology·2021
Same author

Multivariate data analysis identifies natural clusters of Tuberous Sclerosis Complex Associated Neuropsychiatric Disorders (TAND).

Orphanet journal of rare diseases·2021
Same author

Endothelial <i>GNAQ</i> p.R183Q Increases ANGPT2 (Angiopoietin-2) and Drives Formation of Enlarged Blood Vessels.

Arteriosclerosis, thrombosis, and vascular biology·2021
Same author

Profile of Autism Spectrum Disorder in Tuberous Sclerosis Complex: Results from a Longitudinal, Prospective, Multisite Study.

Annals of neurology·2021
Same author

Enhanced prime editing systems by manipulating cellular determinants of editing outcomes.

Cell·2021

Related Experiment Video

Updated: Jun 4, 2026

Transcranial Direct Current Stimulation (tDCS) in Mice
11:54

Transcranial Direct Current Stimulation (tDCS) in Mice

Published on: September 23, 2018

TSC1/TSC2 signaling in the CNS.

Juliette M Han1, Mustafa Sahin

  • 1The FM Kirby Neurobiology Center, Department of Neurology, Children's Hospital Boston, Harvard Medical School, Boston, MA 02115, USA.

FEBS Letters
|February 19, 2011
PubMed
Summary

Tuberous sclerosis complex (TSC) involves mutations in TSC1/2, impacting cell growth via the mTORC1 pathway. In the central nervous system (CNS), TSC1/2 signaling uniquely regulates neural connectivity.

Area of Science:

  • Neuroscience
  • Genetics
  • Cell Biology

Background:

  • Tuberous sclerosis complex (TSC) is a hereditary disorder caused by inactivating mutations in TSC1 or TSC2.
  • The TSC1/2 complex is a key regulator of the mTORC1 signaling pathway, which controls cell growth and proliferation.
  • While TSC is linked to benign tumors in various organs, its role in the central nervous system (CNS) is complex.

Purpose of the Study:

  • To review the multifaceted roles of TSC1/2 signaling specifically within the CNS.
  • To highlight how TSC1/2 influences neural connectivity through distinct mechanisms.

Main Methods:

  • Review of existing literature on TSC1/2 signaling.
  • Analysis of TSC1/2 functions in different cell types, developmental stages, and subcellular locations within the CNS.

More Related Videos

Transcranial Electrical Brain Stimulation in Alert Rodents
10:08

Transcranial Electrical Brain Stimulation in Alert Rodents

Published on: November 2, 2017

A Thin-skull Window Technique for Chronic Two-photon In vivo Imaging of Murine Microglia in Models of Neuroinflammation
12:07

A Thin-skull Window Technique for Chronic Two-photon In vivo Imaging of Murine Microglia in Models of Neuroinflammation

Published on: September 19, 2010

Related Experiment Videos

Last Updated: Jun 4, 2026

Transcranial Direct Current Stimulation (tDCS) in Mice
11:54

Transcranial Direct Current Stimulation (tDCS) in Mice

Published on: September 23, 2018

Transcranial Electrical Brain Stimulation in Alert Rodents
10:08

Transcranial Electrical Brain Stimulation in Alert Rodents

Published on: November 2, 2017

A Thin-skull Window Technique for Chronic Two-photon In vivo Imaging of Murine Microglia in Models of Neuroinflammation
12:07

A Thin-skull Window Technique for Chronic Two-photon In vivo Imaging of Murine Microglia in Models of Neuroinflammation

Published on: September 19, 2010

Main Results:

  • TSC1/2 signaling in the CNS extends beyond cell growth/proliferation regulation.
  • Its functions are context-dependent, varying with cell type, developmental stage, and subcellular localization.
  • Proper neural connectivity relies on these intricate TSC1/2-mediated systems.

Conclusions:

  • TSC1/2 signaling plays a critical, diverse role in CNS development and function.
  • Understanding these CNS-specific roles is crucial for comprehending TSC and related neurological conditions.