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Updated: Jun 4, 2026

A Mouse Abdominal Aortic Aneurysm Model by Periadventitial Calcium Chloride and Elastase Infiltration
Published on: August 2, 2024
Pharmacological interventions to attenuate the expansion of abdominal aortic aneurysm (AAA) - a systematic review
1Department of Surgical Sciences, Section of Surgery, Uppsala University Hospital, SE 751 85 Uppsala, Sweden. david.bergqvist@surgsci.uu.se
Introduction:
Is it possible by pharmacological methods to attenuate the expansion rate of abdominal aortic aneurysms?
Method:
An Internet-based systematic literature search was performed to identify published reports on pharmacological methods to influence aneurysmal expansion rate.
Results:
Of an original 450 articles, 21 remained to review: they included 15 cohort studies with 12,321 patients and seven randomised clinical trials (RCTs) with 1069 patients. Most studies are performed without a pre-study sample size calculation. There is no consistent pattern of pharmacological influence on expansion rate, but statins, non-steroidal anti-inflammatory drugs (NSAIDs) and macrolides should be further evaluated.
Conclusion:
Properly designed RCTs are needed before conclusions can be drawn on the possibility to pharmacologically attenuate aneurysmal expansion and prevent rupture.
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