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Related Concept Videos

Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their access...
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic cells are...
Embryonic Stem Cells00:57

Embryonic Stem Cells

Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
Source And Potency Of Stem Cells01:27

Source And Potency Of Stem Cells

Stem cells are undifferentiated cells with extensive self-renewal properties that help them maintain their population during the fetal and adult stages of life. They can specialize in all cell types of the human body. However, their differential potential may vary and can be classified into five types. Stem cells can be (1) Totipotent, (2) Pluripotent, (3) Multipotent, (4) Oligopotent, and (5) Unipotent. Each stem cell has a specific origin; the fertilized egg or zygote is a totipotent cell and...

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Establishing Organoids from Human Tooth as a Powerful Tool Toward Mechanistic Research and Regenerative Therapy
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Stem cells in tooth tissue regeneration--challenges and limitations.

Bülend Inanç1, Y Murat Elçin

  • 1Tissue Engineering, Biomaterials & Nanobiotechnology Laboratory, Ankara University Stem Cell Institute and Faculty of Science, Ankara, 06100, Turkey.

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Stem cells offer promise for regenerative dentistry, with adult stem cells found in teeth. However, clinical applications for tooth regeneration remain challenging.

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Last Updated: Jun 4, 2026

Establishing Organoids from Human Tooth as a Powerful Tool Toward Mechanistic Research and Regenerative Therapy
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Isolation, Characterization and Comparative Differentiation of Human Dental Pulp Stem Cells Derived from Permanent Teeth by Using Two Different Methods
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Isolation, Characterization and Comparative Differentiation of Human Dental Pulp Stem Cells Derived from Permanent Teeth by Using Two Different Methods

Published on: November 24, 2012

Area of Science:

  • Biomedical Engineering
  • Stem Cell Biology
  • Regenerative Medicine
  • Dental Research

Background:

  • Recent decades have seen accelerated stem cell research, increasing interest in clinical applications across medicine, including regenerative dentistry.
  • Embryonic and adult stem cells are key sources for ex-vivo tissue engineering strategies.
  • Adult stem cells are vital for tissue homeostasis and regeneration, present in all living tissues.

Purpose of the Study:

  • To explore the potential of stem cells, both embryonic and adult, for regenerative dentistry applications.
  • To investigate the presence and characteristics of adult stem cells within human tooth structures.
  • To review proposed strategies for tooth regeneration using stem cells.

Main Methods:

  • Review of existing literature on stem cell biology and regenerative dentistry.
  • Analysis of experimental findings regarding stem cell populations in periodontal and endodontic tissues.
  • Evaluation of proposed stem cell-based strategies for tooth regeneration.

Main Results:

  • Adult stem cell populations are present in periodontal and endodontic tissues of the tooth.
  • These adult stem cells exhibit characteristics of early cellular differentiation.
  • Numerous strategies utilizing embryonic and adult stem cells for tooth regeneration have been proposed.

Conclusions:

  • Adult stem cells represent a promising source for regenerative dentistry.
  • The presence of stem cells in dental tissues supports their potential for regeneration.
  • Despite proposed strategies, successful clinical application of stem cell-based tooth regeneration remains a significant challenge.