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[Thyroid disease in progressive systemic sclerosis].

M F Besançon1, L Guzmán, M Grisanti

  • 1Servicio de Medicina, Hospital del Salvador, Universidad de Chile, Santiago.

Revista Medica De Chile
|April 1, 1990
PubMed
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Thyroid disease frequently affects patients with progressive systemic sclerosis (PSS). Comprehensive clinical and laboratory evaluations are essential for diagnosing thyroid dysfunction in PSS patients.

Area of Science:

  • Endocrinology
  • Rheumatology
  • Immunology

Context:

  • Progressive systemic sclerosis (PSS) is a multisystem autoimmune disease with variable clinical manifestations.
  • The association between PSS and thyroid disease remains debated, necessitating further investigation.

Purpose:

  • To investigate the prevalence and nature of thyroid dysfunction in patients with proven PSS.
  • To determine the specific types of thyroid pathology associated with PSS, including the CREST variant.

Summary:

  • This study evaluated 28 patients with PSS, assessing thyroid function (T3, T4, TSH, Tg) and autoantibodies.
  • Thyroid dysfunction was identified in 43% of patients, including goiter, autoimmune thyroiditis, hypothyroidism, hyperthyroidism, and subacute thyroiditis.
  • The CREST variant of PSS showed a higher association with thyroid pathology.

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Impact:

  • Findings suggest a frequent association between thyroid disease and PSS, underscoring the need for routine thyroid screening in these patients.
  • Highlights the importance of a thorough clinical and laboratory assessment for early detection and management of thyroid complications in PSS.